Post-Renal Transplantation Bone Health in Children Evaluated by Means of Quantitative Ultrasound and Densitometry
Por:
Gonzalez-Jorge, A. L., Enciso, S., Reyes, A., Hernandez, A. M., Ortiz, L., Aldana, R., Velasquez-Forero, F., Ambrosi, R., Clark, P., Mendez, L., Rivas-Ruiz, R., Medeiros, M.
Publicada:
1 mar 2016
Resumen:
Background. Patients with end-stage renal disease develop bone mineral
disease, which is not always resolved after a successful renal
transplantation; moreover, some of the immunosuppressants used to
prevent graft rejection may affect bone health. The aim of this study
was to evaluate bone health in post-renal transplantation children with
the use of quantitative ultrasound (QUS) and dual-energy X-ray
absorptiometry (DXA).
Methods. A descriptive study was performed in children >3 months after
renal transplantation and with stable function of graft. Radial QUS and
DXA (lumbar spine and total body less head (TBLH) were performed on the
same day.
Results. A total of 35 patients were included. Mean age was 13.9 +/- 3.9
years. Ten subjects had total bone density score <2 (28.5%), 4 a lumbar
spine (Ll-L4) Z-score of <2 (11.4%) as well as TBLH <2, and 6 subjects
had a radial QUS Z-score of <2 (17.1%), and only 2 of them had
concomitant Z-score <2 with the use of DXA. There was a positive
non-significant correlation between TBLH and radial QUS Z-scores
(Pearson r = 0.317; P =.016) and a positive significant correlation of
DXA lumbar spine and radial QUS Z-scores (Pearson r = 0.452; P =.014).
Conclusions. Despite a good correlation between TBLH and QUS Z-scores,
there are subjects that can be considered normal by QUS and have
osteopenia by TBLH DXA and vice versa; this could be due to the
different bone areas evaluated.
Filiaciones:
Gonzalez-Jorge, A. L.:
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Enciso, S.:
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Reyes, A.:
Hosp Infantil Mexico Dr Federico Gomez, Ctr Estudios Econ & Sociales Salud, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Hernandez, A. M.:
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Ortiz, L.:
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Aldana, R.:
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Velasquez-Forero, F.:
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Ambrosi, R.:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Epidemiol Clin, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Clark, P.:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Epidemiol Clin, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Mendez, L.:
Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Epidemiol Clin, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
Rivas-Ruiz, R.:
Inst Mexicano Seguro Social, Ctr Adiestramiento Invest Clin Coordinac Invest S, Mexico City, DF, Mexico
Medeiros, M.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 04510, DF, Mexico
Hosp Infantil Mexico Dr Federico Gomez, Lab Nefrol & Metab Mineral Oseo, Dr Marquez 162 Col Doctores, Mexico City 06720, DF, Mexico
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