Differential Vascular Permeability Along the Forebrain Ventricular Neurogenic Niche in the Adult Murine Brain
Por:
Colin-Castelan, Dannia, Ramirez-Santos, Jesus, Gutierrez-Ospina, Gabriel
Publicada:
1 feb 2016
Categoría:
Cellular and Molecular Neuroscience
Resumen:
Adult neurogenesis is influenced by blood-borne factors. In this
context, greater or lesser vascular permeability along neurogenic niches
would expose differentially neural stem cells (NSCs), transit amplifying
cells (TACs), and neuroblasts to such factors. Here we evaluate
endothelial cell morphology and vascular permeability along the
fore-brain neurogenic niche in the adult brain. Our results confirm that
the subventricular zone (SVZ) contains highly permeable, discontinuous
blood vessels, some of which allow the extravasation of molecules larger
than those previously reported. In contrast, the rostral migratory
stream (RMS) and the olfactory bulb core (OBc) display mostly
impermeable, continuous blood vessels. These results imply that NSCs,
TACs, and neuroblasts located within the SVZ are exposed more readily to
blood-borne molecules, including those with very high molecular weights,
than those positioned along the RMS and the OBc, subregions in which
every stage of neurogenesis also takes place. These observations suggest
that the existence of specialized vascular niches is not a precondition
for neurogenesis to occur; specialized vascular beds might be essential
for keeping high rates of proliferation and/or differential
differentiation of neural precursors located at distinct domains. (c)
2015 Wiley Periodicals, Inc.
Filiaciones:
Colin-Castelan, Dannia:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Ciudad De Mexico 04510, Mexico
Ramirez-Santos, Jesus:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Gutierrez-Ospina, Gabriel:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Fisiol, Inst Invest Biomed, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Psicol, Coordinac Psicobiol, Ciudad De Mexico 04510, Mexico
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