Non-Criteria or Seronegative Obstetric Antiphospholipid Syndrome
Por:
Jara, Luis J., Medina, Gabriela, Cruz-Cruz, Polite, Olivares-Rivera, Javier, Duarte-Salazar, Carolina, Saavedra, Miguel A.
Publicada:
1 jun 2017
Categoría:
Medicine (miscellaneous)
Resumen:
Obstetric antiphospholipid syndrome (Obs-APS) is one of I the most
commonly identified causes of recurrent pregnancy loss and its accurate
diagnosis is a requirement for optimal treatment. Some patients do not
fulfill the revised Sapporo classification criteria, the original APS
classification criteria, and are considered to be non-criteria Obs-APS.
In these patients with non-criteria, there is controversy about their
inclusion within the spectrum of APS and eventually their treatment as
having Obs-APS. A subset of patients may also have clinical
characteristics of Obs-APS even though lupus anticoagulant,
anticardiolipin antibodies, and anti-beta 2 glycoprotein I antibodies
are consistently negative. These patients are recognized as seronegative
Obs-APS.
We reviewed evidence of non-criteria Obs-APS and discuss a case of a
woman with a diagnosis of active systemic lupus erythematosus and
non-criteria Obs-APS with four consecutive pregnancy losses. After an
accurate diagnosis the patient received prenatal counseling and
benefited from the optimal treatment of Obs-APS that led to a successful
pregnancy. The applicability of this successful experience about
outcomes in women with non-criteria (seronegative) Obs-APS is also
evaluated.
Filiaciones:
Jara, Luis J.:
IMSS, Hosp Especialidades Ctr Med La Raza, Direct Educ & Res, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Mexico City, DF, Mexico
Medina, Gabriela:
IMSS, Hosp Especialidades Ctr Med La Raza, Clin Res Unit, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Mexico City, DF, Mexico
Cruz-Cruz, Polite:
IMSS, Gynecol & Obstet Hosp Ctr Med La Raza, Mexico City, DF, Mexico
Olivares-Rivera, Javier:
Univ Sonora, Fac Med, Hermosillo, Sonora, Mexico
Duarte-Salazar, Carolina:
INR, Rheumatol Dept, Mexico City, DF, Mexico
Saavedra, Miguel A.:
IMSS, Hosp Especialidades Ctr Med La Raza, Rheumatol Dept, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Mexico City, DF, Mexico
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