Ophthalmic indications of amniotic membrane transplantation in Mexico: an eight years Amniotic Membrane Bank experience
Por:
Chavez-Garcia, Cesar, Jimenez-Corona, Aida, Graue-Hernandez, Enrique O., Zaga-Clavellina, Veronica, Garcia-Mejia, Mariana, Jimenez-Martinez, Maria Carmen, Garfias, Yonathan
Publicada:
1 jun 2016
Resumen:
Amniotic membrane, the inner layer of the placenta, has biological properties (e.g. promotes epithelization, reduces fibrosis, secretes antimicrobial products and inhibits immune responses) which make it a useful option for several ophthalmologic procedures, especially those involving the ocular surface. Its use in eye surgery has been reported by other authors. To our knowledge, there is a lack of descriptive studies on surgical indications using amniotic membrane in Mexican population. Here we describe the eight years Amniotic Membrane Bank experience in Mexico, including a detailed protocol of the donors selection, tissue harvesting, preparation, storage and distribution of amniotic membrane since its establishment in 2007. Moreover, we describe the Ophthalmological indications of amniotic membrane transplantation of the total of 1686 amniotic membranes fragments used during eight years. The five most common indications for amniotic membrane transplantation were pterygium (46 %), corneal ulcers (12.6 %), conjunctival surface repair (11.1 %), neoplasms (7.4 %), and persistent epithelial defects (7.3 %). In addition, we compared the indications of amniotic membrane use in two different types of Institutions: general hospitals and ophthalmologic reference hospitals. We found interesting differences between the indications and use rates between these institutions, although pterygium was the most frequent pathology that amniotic membrane fragments were used in both institutions, there was up to a five-fold increase in the use of amniotic membrane for correction of persistent epithelial defects in reference hospitals which could be explained due to the more complex and severe ophthalmological pathologies admitted in reference hospitals. In conclusion, Amniotic Membrane is used in a numerous ocular pathologies and especially on pterygium in our Mexican population. © 2015, Springer Science+Business Media Dordrecht.
Filiaciones:
Chavez-Garcia, Cesar:
Inst Oftalmol Conde Valenciana, Amniot Membrane Bank, Cell & Tissue Biol Res Unit, Chimalpopoca 14, Mexico City 06800, DF, Mexico
Jimenez-Corona, Aida:
Inst Oftalmol Conde Valenciana, Dept Ocular Epidemiol, Chimalpopoca 14, Mexico City 06800, DF, Mexico
Graue-Hernandez, Enrique O.:
Inst Oftalmol Conde Valenciana, Dept Cornea & Refract Surg, Chimalpopoca 14, Mexico City 06800, DF, Mexico
Zaga-Clavellina, Veronica:
Inst Nacl Perinatol Isidro Espinosa Ios Reyes, Immunobiochem Dept, Montes Urales 800, Mexico City 11000, DF, Mexico
Garcia-Mejia, Mariana:
Inst Oftalmol Conde Valenciana, Amniot Membrane Bank, Cell & Tissue Biol Res Unit, Chimalpopoca 14, Mexico City 06800, DF, Mexico
Jimenez-Martinez, Maria Carmen:
Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Ave Univ 3000, Mexico City 04510, DF, Mexico
Garfias, Yonathan:
Inst Oftalmol Conde Valenciana, Amniot Membrane Bank, Cell & Tissue Biol Res Unit, Chimalpopoca 14, Mexico City 06800, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Ave Univ 3000, Mexico City 04510, DF, Mexico
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