An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children
Por:
Moran-Ramos, Sofia, Ocampo-Medina, Elvira, Gutierrez-Aguilar, Ruth, Macias-Kauffer, Luis, Villamil-Ramirez, Hugo, Lopez-Contreras, Blanca E., Leon-Mimila, Paola, Vega-Badillo, Joel, Gutierrez-Vidal, Roxana, Villarruel-Vazquez, Ricardo, Serrano-Carbajal, Erandi, Del-Rio-Navarro, Blanca E., Huertas-Vazquez, Adriana, Villarreal-Molina, Teresa, Ibarra-Gonzalez, Isabel, Vela-Amieva, Marcela, Aguilar-Salinas, Carlos A., Canizales-Quinteros, Samuel
Publicada:
17 jul 2017
Categoría:
Multidisciplinary
Resumen:
Childhood obesity is associated with a number of metabolic abnormalities
leading to increased cardiovascular risk. Metabolites can be useful as
early biomarkers and new targets to promote early intervention beginning
in school age. Thus, we aimed to identify metabolomic profiles
associated with obesity and obesity-related metabolic traits. We used
data from the Obesity Research Study for Mexican children (ORSMEC) in
Mexico City and included a case control (n = 1120), cross-sectional (n =
554) and a longitudinal study (n = 301) of 6-12-year-old children.
Forty-two metabolites were measured using electrospray MS/MS and
multivariate regression models were used to test associations of
metabolomic profiles with anthropometric, clinical and biochemical
parameters. Principal component analysis showed a serum amino acid
signature composed of arginine, leucine/isoleucine, phenylalanine,
tyrosine, valine and proline significantly associated with obesity (OR =
1.57; 95% CI 1.45-1.69, P = 3.84 x 10(-3)1) and serum triglycerides
(TG) (beta = 0.067, P = 4.5 x 10(-21)). These associations were
validated in the cross-sectional study (P < 0.0001). In the longitudinal
cohort, the amino acid signature was associated with serum TG and with
the risk of hypertriglyceridemia after 2 years (OR = 1.19; 95% CI
1.03-1.39, P = 0.016). This study shows that an amino acid signature
significantly associated with childhood obesity, is an independent risk
factor of future hypertriglyceridemia in children.
Filiaciones:
Moran-Ramos, Sofia:
Consejo Nacl Ciencia & Tecnol CONACyT, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Ocampo-Medina, Elvira:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Gutierrez-Aguilar, Ruth:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico
Macias-Kauffer, Luis:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Villamil-Ramirez, Hugo:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Lopez-Contreras, Blanca E.:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Leon-Mimila, Paola:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Vega-Badillo, Joel:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Gutierrez-Vidal, Roxana:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Villarruel-Vazquez, Ricardo:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Serrano-Carbajal, Erandi:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
Del-Rio-Navarro, Blanca E.:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
Huertas-Vazquez, Adriana:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
Villarreal-Molina, Teresa:
INMEGEN, Lab Enfermedades Cardiovasc, Mexico City, DF, Mexico
Inst Nacl Pediat, Lab Errores Innatos Metab & Tamiz, Mexico City, DF, Mexico
Ibarra-Gonzalez, Isabel:
Univ Nacl Autonoma Mexico, Inst Nacl Pediat, Inst Invest Biomed, Mexico City, DF, Mexico
Inst Nacl Pediat, Lab Errores Innatos Metab & Tamiz, Mexico City, DF, Mexico
Aguilar-Salinas, Carlos A.:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Mexico City, DF, Mexico
Canizales-Quinteros, Samuel:
Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Unidad Genom Poblac Aplicada Salud, Fac Quim, Mexico City, DF, Mexico
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