Tributyltin(IV) Schiff base complexes with amino acid derivatives: synthesis, characterization and biological activity
Por:
Camacho-Camacho, Carlos, Rojas-Oviedo, Irma, Garza-Ortiz, Ariadna, Toscano, Ruben Alfredo, Sanchez-Sanchez, Luis, Cardenas, Jorge, Lopez-Munoz, Hugo
Publicada:
1 abr 2016
Resumen:
The synthesis in one-pot reactions and structural characterization of
six new tri-n-butyltin(IV) derivatives of Schiff bases are reported. The
compounds are derived from a condensation reaction between l-alanine,
l-valine, l-isoleucine, l-methionine, l-phenylalanine or l-tryptophan
and 3,5-di-tert-butyl-2-hydroxybenzaldehyde. Characterization was
completed using elemental analysis, infrared spectroscopy, mass
spectrometry, one- and two-dimensional solution NMR (H-1, C-13 and
Sn-119) as well as solid-state Sn-119 NMR. In addition, the crystal
structures of three of the compounds were confirmed using single-crystal
X-ray diffraction. Although five-coordinated and polymeric in the solid
state, the tin compounds are four-coordinated and monomeric in solution.
The coordination environment around the triorganotin units comprises
three carbon atoms and two oxygen atoms from two ligands in a trigonal
bipyramidal geometry. The anti-proliferative effect of these compounds
on the cervical carcinoma cell lines HeLa, CaSki and ViBo was screened
in vitro, the compounds showing cytotoxic activity against all three
strains and null or low cytotoxic activity (necrotic) as well. Copyright
(c) 2016 John Wiley & Sons, Ltd.
Filiaciones:
Camacho-Camacho, Carlos:
Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Calzada De Hueso 1100, Mexico City 04960, DF, Mexico
Rojas-Oviedo, Irma:
Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Calzada De Hueso 1100, Mexico City 04960, DF, Mexico
Garza-Ortiz, Ariadna:
Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Calzada De Hueso 1100, Mexico City 04960, DF, Mexico
Toscano, Ruben Alfredo:
Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior S-N, Mexico City 04510, DF, Mexico
Sanchez-Sanchez, Luis:
Unidad Multidisciplinaria Invest Expt Zaragoza, Ave Batalla 5 Mayo S-N, Mexico City 09230, DF, Mexico
Cardenas, Jorge:
Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior S-N, Mexico City 04510, DF, Mexico
Lopez-Munoz, Hugo:
Unidad Multidisciplinaria Invest Expt Zaragoza, Ave Batalla 5 Mayo S-N, Mexico City 09230, DF, Mexico
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