An integrative overview of the cannabinergic system and mental health
Por:
Prospero Garcia, Oscar E., Rueda Orozco, Pavel E., Amancio Belmont, Octavio, Ruiz Contreras, Alejandra E., Mendez Diaz, Monica
Publicada:
1 may 2017
Resumen:
Background. The endocannabinoid system (eCBs) is one of the modulatory
systems widely expressed in the brain. It consists of receptors
expressed in the cytoplasmic (CB1 and CB2), the mitochondria! membrane
(CB1), and the endogenous ligands known as endocannabinoids, such as
anandamide, 2AG and oleamide. CB1 has been found in excitatory and
inhibitory neurons in the pre- and post-synaptic membranes. It is
expressed in several brain areas such as the hippocampus, dorsal, and
ventral striatum, amygdala and prefrontal cortex. The eCBs has been
involved in the regulation of learning and memory, mood, energy balance,
sleep, and drug addiction. Objective. Integrate existing information
about the eCBs and its role in brain function and mental health. Method.
Review of the information of basic and clinical relevance obtained from
indexed scientific journals (PubMed/Medline, Scopus). Results. Basic and
clinical research on eCBs related to central nervous system function is
described. Discussion and conclusion. At present, the study of eCBs is
of importance. The development of drugs that affect this system may be
clinically useful to control different debilitating diseases. This is an
area of interest to the scientific community and health care providers.
Filiaciones:
Prospero Garcia, Oscar E.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Cannabinoides, Mexico City, DF, Mexico
Rueda Orozco, Pavel E.:
Univ Nacl Autonoma Mexico, Dept Neurofisiol Desarrollo & Neurofisiol, Inst Neurobiol, Mexico City, DF, Mexico
Amancio Belmont, Octavio:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Cannabinoides, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Lab Neurogenom Cognit, Fac Psicol, Coordinat Psicobiol & Neurociencias, Mexico City, DF, Mexico
Ruiz Contreras, Alejandra E.:
Univ Nacl Autonoma Mexico, Lab Neurogenom Cognit, Fac Psicol, Coordinat Psicobiol & Neurociencias, Mexico City, DF, Mexico
Mendez Diaz, Monica:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Cannabinoides, Mexico City, DF, Mexico
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