Exposures to fine particulate matter (PM2.5) and ozone above USA standards are associated with auditory brainstem dysmorphology and abnormal auditory brainstem evoked potentials in healthy young dogs
Por:
Calderón-Garcidueñas L., González-González L.O., Kulesza R.J., Fech T.M., Pérez-Guillé G., Luna, M.A.J.-B., Soriano-Rosales R.E., Solorio E., Miramontes-Higuera, J.D.J., Gómez-Maqueo Chew A., Bernal-Morúa A.F., Mukherjee P.S., Torres-Jardón R., Mills P.C., Wilson W.J., Pérez-Guillé B., D'Angiulli A.
Publicada:
1 oct 2017
Resumen:
Background: Delayed central conduction times in the auditory brainstem
have been observed in Mexico City (MC) healthy children exposed to fine
particulate matter (PM2.5) and ozone (O-3) above the current United
States Environmental Protection Agency (US-EPA) standards. MC children
have a synuclein brainstem accumulation and medial superior olivary
complex (MSO) dysmorphology. The present study used a dog model to
investigate the potential effects of air pollution on the function and
morphology of the auditory brainstem.
Methodology: Twenty-four dogs living in clean air v MC, average age 37.1
+/- 26.3 months, underwent brainstem auditory evoked potential (BAEP)
measurements. Eight dogs (4 MC, 4 Controls) were analysed for auditory
brainstem morphology and histopathology.
Results: MC dogs showed ventral cochlear nuclei hypotrophy and MSO
dysmorphology with a significant decrease in cell body size, decreased
neuronal packing density with regions in the nucleus devoid of neurons
and marked gliosis. MC dogs showed significant delayed BAEP absolute
wave I, III and V latencies compared to controls.
Conclusions: MC dogs show auditory nuclei dysmorphology and BAEPs
consistent with an alteration of the generator sites of the auditory
brainstem response waveform. This study puts forward the usefulness of
BAEPs to study auditory brainstem neurodegenerative changes associated
with air pollution in dogs. Recognition of the role of non-invasive
BAEPs in urban dogs is warranted to elucidate novel neurodegenerative
pathways link to air pollution and a promising early diagnostic strategy
for Alzheimer's Disease.
Filiaciones:
Calderón-Garcidueñas L.:
The University of Montana, Missoula, MT 59812, United States
Universidad del Valle de México, Mexico
González-González L.O.:
Instituto Nacional de Pediatría, Mexico City, 04530, Mexico
Kulesza R.J.:
Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, United States
Fech T.M.:
Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, United States
Pérez-Guillé G.:
Instituto Nacional de Pediatría, Mexico City, 04530, Mexico
Soriano-Rosales R.E.:
Instituto Nacional de Pediatría, Mexico City, 04530, Mexico
Solorio E.:
Instituto Nacional de Pediatría, Mexico City, 04530, Mexico
Gómez-Maqueo Chew A.:
Universidad del Valle de México, Mexico
Bernal-Morúa A.F.:
Universidad del Valle de México, Mexico
Mukherjee P.S.:
Mathematics Department, Boise State University, Boise, ID, United States
Torres-Jardón R.:
Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Mills P.C.:
The University of QueenslandQLD 4072, Australia
Wilson W.J.:
The University of QueenslandQLD 4072, Australia
Pérez-Guillé B.:
Instituto Nacional de Pediatría, Mexico City, 04530, Mexico
D'Angiulli A.:
Department of Psychology, Carleton University, Ottawa, Ontario K1S 5B6, Canada
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