Understanding tumor anabolism and patient catabolism in cancer-associated cachexia
Por:
Schcolnik-Cabrera, Alejandro, Chavez-Blanco, Alma, Dominguez-Gomez, Guadalupe, Duenas-Gonzalez, Alfonso
Publicada:
1 ene 2017
Resumen:
Cachexia is a multifactorial paraneoplastic syndrome commonly associated
with advanced stages of cancer. Cachexia is responsible for poor
responses to antitumoral treatment and death in close to one-third of
affected patients. There is still an incomplete understanding of the
metabolic dysregulation induced by a tumor that leads to the appearance
and persistence of cachexia. Furthermore, cachexia is irreversible, and
there are currently no guidelines for its diagnosis or treatments for
it. In this review, we aim to discuss the current knowledge about
cancer-associated cachexia, starting with generalities about cancer as
the generator of this syndrome, then analyzing the characteristics of
cachexia at the biochemical and metabolic levels in both the tumor and
the patient, and finally discussing current therapeutic approaches to
treating cancer-associated cachexia.
Filiaciones:
Schcolnik-Cabrera, Alejandro:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Chavez-Blanco, Alma:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Dominguez-Gomez, Guadalupe:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Duenas-Gonzalez, Alfonso:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City, DF, Mexico
|