Nucleo-cytoplasmic transport of estrogen receptor alpha in breast cancer cells
Por:
Tecalco-Cruz, Angeles C., Perez-Alvarado, Issis A., Ramirez-Jarquin, Josue O., Rocha-Zavaleta, Leticia
Publicada:
1 jun 2017
Categoría:
Cell biology
Resumen:
Approximately 70% cases of breast cancers exhibit high expression and
activity levels of estrogen receptor alpha (ERa), a transcription
regulator that induces the expression of genes associated with cellular
proliferation and survival. These nuclear functions of the receptor are
associated with the development of breast cancer. However, ERa
localization is not static, but rather, dynamic with continuous
shuttling between the nucleus and the cytoplasm. Interestingly, both the
nuclear import and export of ERa are modulated by several stimuli that
include estradiol, antiestrogens, and growth factors. As ERa nuclear
accumulation is critical to the regulation of gene expression, nuclear
export of this receptor modulates the intensity and duration of its
transcriptional activity. Thus, the subcellular spatial distribution of
ERa ensures tight modulation of its concentration in cellular
compartMents, as well as of its nuclear and extranuclear functions. In
this review, we will discuss current findings regarding the biological
importance of molecular mechanisms of, and proteins responsible for, the
nuclear import and export of ERa in breast cancer cells.
Filiaciones:
Tecalco-Cruz, Angeles C.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Programa Invest Canc Mama, Apdo Postal, Mexico City 04510, DF, Mexico
Perez-Alvarado, Issis A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Programa Invest Canc Mama, Apdo Postal, Mexico City 04510, DF, Mexico
Ramirez-Jarquin, Josue O.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Apdo Postal, Mexico City 04510, DF, Mexico
Rocha-Zavaleta, Leticia:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Programa Invest Canc Mama, Apdo Postal, Mexico City 04510, DF, Mexico
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