Knowns and unknowns of membrane lipid synthesis in streptomycetes
Por:
Sandoval-Calderón M., Guan Z., Sohlenkamp C.
Publicada:
1 oct 2017
Resumen:
Bacteria belonging to the genus Streptomyces are among the most prolific
producers of antibiotics. Research on cellular membrane biosynthesis and
turnover is lagging behind in Streptomyces compared to related organisms
like Mycobacterium tuberculosis. While natural products discovery in
Streptomyces is evidently a priority in order to discover new
antibiotics to combat the increase in antibiotic resistant pathogens, a
better understanding of this cellular compartment should provide
insights into the interplay between core and secondary metabolism.
However, some of the pathways for membrane lipid biosynthesis are still
incomplete. In addition, while it has become clear that remodelling of
the membrane is necessary for coping with environmental stress and for
morphological differentiation, the detailed mechanisms of these
adaptations remain elusive. Here, we aim to provide a summary of what is
known about the polar lipid composition in Streptomyces, the
biosynthetic pathways of polar lipids, and to highlight current gaps in
understanding function, dynamics and biosynthesis of these essential
molecules. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et
Biologie Moleculaire (SFBBM). All rights reserved.
Filiaciones:
Sandoval-Calderón M.:
Univ Nacl Autonoma Mexico, Ctr Ciencias Genom, Av Univ S-N,Apdo Postal 565-A, Cuernavaca 62210, Morelos, Mexico
Johannes Gutenberg Univ Mainz, Dept Evolutionary Ecol, Mainz, Germany
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico
Department for Evolutionary Ecology, Johannes Gutenberg University, Mainz, Germany
Guan Z.:
Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA
Department of Biochemistry, Duke University Medical Center, Durham, NC, United States
Sohlenkamp C.:
Univ Nacl Autonoma Mexico, Ctr Ciencias Genom, Av Univ S-N,Apdo Postal 565-A, Cuernavaca 62210, Morelos, Mexico
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico
|