Nonaqueous Synthesis of Macroporous Nanocomposites Using High Internal Phase Emulsion Stabilized by Nanohydroxyapatite
Por:
Carranza A., Romero-Perez D., Almanza-Reyes H., Bogdanchikova N., Juarez-Moreno K., Pojman J.A., Velasquillo C., Mota-Morales J.D.
Publicada:
21 ago 2017
Resumen:
Nonaqueous high internal phase emulsions (HIPEs) stabilized by
nanohydroxyapatite (NHA)/surfactant hybrids are used as template to
prepare interconnected porous monoliths. The use of a sustainable deep
eutectic solvent (DES) comprised of urea and choline chloride (UChCl),
as the internal phase, enables an efficient interaction of
NHA/surfactant at the HIPE interface, which in turn allows for a
bottom-up approach to selective interfacial functionalization of
poly(HIPE's) voids surface after polymerization of methyl methacrylate
continuous phase. UChCl DES is a suitable internal phase for HIPE
polymerization thanks to its polarity and viscosity that provides
further stabilization of the emulsion precursor. This simple synthetic
method produces well-defined functional poly(methyl methacrylate) (pMMA)
scaffolds with tunable mechanical properties and exposed NHA at the
inner surface. Based upon a preliminary biocompatibility in vivo test,
poly(HIPEs) show enhanced biocompatibility in comparison with sterile
gauze. Interestingly, pMMA NHA nanocomposite scaffold remains in the
tissue after 90 d allowing little ingrowth of cells while causing a
normal foreign-body reaction in the rats' muscle tissue. Interfacial
functionalization of well-defined interconnected porous monoliths with
nanomaterials via DES-based HIPEs approach is a promising method that
encourages further investigation for the synthesis of biodegradable and
biocompatible scaffolds nanocomposites for tissue engineering purposes.
Filiaciones:
Carranza A.:
Louisiana State Univ, Dept Chem, Baton Rouge, LA 70820 USA
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70820, United States
Romero-Perez D.:
Univ Autonoma Baja California, Fac Ciencias Quim & Ingn, Tijuana 22390, Baja California, Mexico
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Tijuana, Baja California 22390, Mexico
Almanza-Reyes H.:
Univ Autonoma Baja California, Fac Med & Psicol, Tijuana 22390, Baja California, Mexico
Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California 22390, Mexico
Bogdanchikova N.:
Univ Nacl Autonoma Mexico, Ctr Nanociencias & Nanotecnol, Ensenada 22860, Baja California, Mexico
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autonoma de Mexico, Ensenada, Baja California 22860, Mexico
Juarez-Moreno K.:
Univ Nacl Autonoma Mexico, Ctr Nanociencias & Nanotecnol, CONACyT, Ensenada 22860, Baja California, Mexico
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autonoma de Mexico, Ensenada, Baja California 22860, Mexico
CONACYT at Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada, Baja California 22860, Mexico
Pojman J.A.:
Louisiana State Univ, Dept Chem, Baton Rouge, LA 70820 USA
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70820, United States
Velasquillo C.:
Inst Nacl Rehabil, Ciudad De Mexico 14389, Mexico
Instituto Nacional de Rehabilitación, Ciudad de México, 14389, Mexico
Mota-Morales J.D.:
Univ Nacl Autonoma Mexico, Ctr Fis Aplicada & Tecnol Avanzada, Campus Juriquilla, Queretaro 76230, Queretaro, Mexico
Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México Campus Juriquilla, Querétaro, Querétaro 76230, Mexico
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