Mirtazapine attenuates cocaine seeking in rats
Por:
Barbosa-Mendez, Susana, Leff, Phillipe, Arias-Caballero, Adriana, Hernandez-Miramontes, Ricardo, Heinze, Gerardo, Salazar-Juarez, Alberto
Publicada:
1 sep 2017
Resumen:
Background: Relapse to cocaine use is a major problem in the clinical
treatment of cocaine addiction. Antidepressants have been studied for
their therapeutic potential to treat cocaine use disorder. Research has
suggested that antidepressants attenuate both drug craving and the
re-acquisition of drug-seeking and drug-taking behaviors. This study
examined the efficacy of mirtazapine, an antidepressant/anxiolytic, in
decreasing cocaine seeking in rats.
Methods: We used the cocaine self-administration paradigm to assess the
effects of mirtazapine on rats trained to self-administer cocaine or
food under a fixed-ratio schedule. Mirtazapine (30 mg/kg, i.p.) was
administered during extinction.
Results: Mirtazapine significantly attenuated non-reinforced lever-press
responses during extinction. Moreover, the mirtazapine dosed for 30 days
during extinction produced sustained attenuation of lever press
responses during re-acquisition of cocaine self-administration, without
changing food-seeking behavior. Our results showed that mirtazapine
attenuated the re-acquisition of cocaine-seeking responses.
Conclusion: Our study pointed to the efficacy of mirtazapine in reducing
the risk of drug relapse during abstinence, suggesting for its potential
use as a novel pharmacological agent to treat drug abuse. (C) 2017
Elsevier Ltd. All rights reserved.
Filiaciones:
Barbosa-Mendez, Susana:
Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Mexico
Natl Inst Psychiat, Mol Neurobiol & Neurochem Addict, Mexico City, DF, Mexico
Leff, Phillipe:
Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Mexico
Natl Inst Psychiat, Mol Neurobiol & Neurochem Addict, Mexico City, DF, Mexico
Arias-Caballero, Adriana:
Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Mexico
Natl Inst Psychiat, Mol Neurobiol & Neurochem Addict, Mexico City, DF, Mexico
Hernandez-Miramontes, Ricardo:
Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Mexico
Natl Inst Psychiat, Mol Neurobiol & Neurochem Addict, Mexico City, DF, Mexico
Heinze, Gerardo:
Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Mexico
Natl Inst Psychiat, Mol Neurobiol & Neurochem Addict, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Sch Med, Dept Psychiat & Mental Hlth, Mexico City, DF, Mexico
Salazar-Juarez, Alberto:
Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry, Ramón de la Fuente Muñiz, Mexico
Natl Inst Psychiat, Mol Neurobiol & Neurochem Addict, Mexico City, DF, Mexico
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