Listeria monocytogenes induces mast cell extracellular traps
Por:
Campillo-Navarro, M., Leyva-Paredes, K., Donis-Maturano, L., González-Jiménez, M., Paredes-Vivas, Y., Cerbulo-Vázquez, A., Serafín-López, J., García-Pérez, B., Ullrich, S.E., Flores-Romo, L., Pérez-Tapia, S.M., Estrada-Parra, S., Estrada-García, I., Chacón-Salinas, R.
Publicada:
1 ene 2017
Resumen:
Mast cells play an essential role in different immunological phenomena including allergy and infectious diseases. Several bacteria induce mast cell activation leading to degranulation and the production of several cytokines and chemokines. However, mast cells also have different microbicidal activities such as phagocytosis and the release of DNA with embedded granular proteins known as Mast Cell Extracellular Traps (MCETs). Although previous reports indicate that extracellular bacteria are able to induce MCETs little is known if intracellular bacteria can induce these structures. In this work, we evaluated MCETs induction by the intracellular bacteria Listeria monocytogenes. We found that mast cells released DNA after stimulation with L. monocytogenes, and this DNA was complexed to histone and tryptase. Before extracellular DNA release, L. monocytogenes induced modifications to the mast cell nuclear envelope and DNA was detected outside the nucleus. L. monocytogenes stimulated mast cells to produce significant amounts of reactive oxygen species (ROS) and blocking NADPH oxidase diminished DNA release by mast cells. Finally, MCETs showed antimicrobial activity against L. monocytogenes that was partially blocked when ?-hexosaminidase activity was inhibited. These results show that L. monocytogenes induces mast cells to produce microbicidal MCETs, suggesting a role for mast cells in containing infection beyond the induction of inflammation. © 2016 Elsevier GmbH
Filiaciones:
Campillo-Navarro, M.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Leyva-Paredes, K.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Donis-Maturano, L.:
Department of Cell Biology, Cinvestav, Instituto Politécnico Nacional, Mexico
González-Jiménez, M.:
Department of Cell Biology, Instituto Nacional de Perinatología, SS, Mexico
Paredes-Vivas, Y.:
Department of Cell Biology, Instituto Nacional de Perinatología, SS, Mexico
Cerbulo-Vázquez, A.:
Woman Hospital, Research Department, SS, Mexico
Serafín-López, J.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
García-Pérez, B.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Ullrich, S.E.:
Department of Immunology and The Center for Cancer Immunology Research, The University of Texas, MD Anderson Cancer Center, United States
The University of Texas Graduate School of Biological Sciences at HoustonTX, United States
Flores-Romo, L.:
Department of Cell Biology, Cinvestav, Instituto Politécnico Nacional, Mexico
Pérez-Tapia, S.M.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Estrada-Parra, S.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Estrada-García, I.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Chacón-Salinas, R.:
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, ENCB-IPN, Mexico
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