Pet evaluation of inflammatory process in Takayasu's arteritis
Por:
Ricalde-Alcocer A., Soto-López M.E., Reyes P., Mendoza G., Cruz P., Meave-González A., Ochoa J.M., Jácome R., Peña-Cabral M.A., Alexánderson-Rosas E.
Publicada:
1 ene 2010
Categoría:
Cardiology and Cardiovascular Medicine
Resumen:
Objective: To determine the application of PET in monitoring patients with Takayasu's arteritis (TA) with inflammatory activity (IA) and its correlation with established clinical criteria. Methods: 35 patients diagnosed with TA were enrolled. Determination of erythrocyte sedimentation rate, C-reactive protein, fibrinogen and a complete blood count was performed and clinical criteria of activity were applied. A baseline PET was performed in all patients. Those who were positive for IA received drug treatment. Among the group of active patients, ten were randomized to undergo another PET scan and clinical criteria determination to evaluate inflammatory activity after 6 months of treatment. We compared clinical criteria with PET capacity to determine IA. The results between the initial and final PET were finally compared. Results: Clinical criteria had a sensitivity of 63% and a specificity of 90% to show IA. Sensitivity decreased after 6 months of treatment to 27%. Discussion: This is the first prospective study that compares the findings of PET before and after treatment for IA in patients with TA. Clinical criteria lack sensitivity for the detection of IA in the follow-up after treatment. Conclusions: PET is a diagnostic technique with high sensitivity and specificity for the diagnosis and monitoring of patients with TA and inflammatory activity. © 2010 Instituto Nacional de Cardiología Ignacio Chávez.
Filiaciones:
Mendoza G.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
Cruz P.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
Meave-González A.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
Ochoa J.M.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
Jácome R.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
Peña-Cabral M.A.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
Alexánderson-Rosas E.:
Unidad PET/CT Ciclotrón, Facultad de Medicina, UNAM, Mexico
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