Effect of nicotine on 3-nitropropionic acid-induced oxidative stress in synaptosomes


Por: Túnez I., Montilla P., Muñoz M.C., Drucker-Colín R.

Publicada: 1 ene 2004
Resumen:
In this paper, the effect of nicotine on the oxidative changes produced by 3-nitropropionic acid (20 mg/kg i.p./day for 4 days) in striatal and cortical synaptosomes of Wistar rats was studied. The effects of 3-nitropropionic acid were evaluated as changes in the quantity of protein carbonyl groups, lipid peroxidation products, superoxide distumase activity and reduced succinate dehydrogenase activity. All changes were prevented by the pre-injection of nicotine (1.5 mg/kg i.p./day), beginning 4 days before and continuing for 4 days after the first injection of 3-nitropropionic acid. These findings indicate that: (i) 3-nitropropionic acid induces a state of oxidative stress in cortical and striatal synaptosomes and (ii) nicotine prevents oxidative stress induced by 3-nitropropinonic acid. In conclusion, the results show the ability of nicotine to modify neural response to 3-nitropropionic acid with the protective mechanism likely involving the antioxidative processes of nicotine. © 2004 Elsevier B.V. All rights reserved.

Filiaciones:
Túnez I.:
 Depto. de Bioquim. Y Biol. Molecular, Facultad de Medicina, Univ. Cordoba, Avda. Menendez P., Spain

Montilla P.:
 Depto. de Bioquim. Y Biol. Molecular, Facultad de Medicina, Univ. Cordoba, Avda. Menendez P., Spain

Muñoz M.C.:
 Depto. de Bioquim. Y Biol. Molecular, Facultad de Medicina, Univ. Cordoba, Avda. Menendez P., Spain

Drucker-Colín R.:
 Departamento de Neurociencias, Instituto de Fisiologia Celular, Univ. Nac. Auton. Mex., Apdo. P., Mexico
ISSN: 00142999
Editorial
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, Países Bajos
Tipo de documento: Article
Volumen: 504 Número: 3
Páginas: 169-175
WOS Id: 000225356600003
ID de PubMed: 15541418