Leishmanicidal and cytotoxic activities of extracts and naturally-occurring compounds from two lauraceae species
Por:
Sánchez-Suárez J., Coy-Barrera E., Cuca L.E., Delgado G.
Publicada:
1 ene 2011
Resumen:
The in vitro leishmanicidal effects of ethanolic extracts and fifteen naturally-occurring compounds (five lignans, eight neolignans, a diterpene and a dihydrochalcone), obtained from Pleurothyrium cinereum and Ocotea macrophylla, were evaluated on promastigotes of Leishmania panamensis and L. braziliensis. In addition, in order to determine the selective action on Leishmania species as a safety principle, in vitro cytotoxicity on J774 cells was also evaluated for test compounds and extracts. One extract and seven compounds showed activity against Leishmania parasites at different levels. Dihydroflavokawin B (8) was found to be the most potent antileishmanial compound on both parasites, whilst (+)-otobaphenol (14), was found to be the most selective compound on L. panamensis.
Filiaciones:
Sánchez-Suárez J.:
Grupo de Investigación en Inmunotoxicología, Departamento de Farmacia, Universidad Nacional de Colombia, 3165120 Bogotá, Colombia
Coy-Barrera E.:
Grupo de Investigación en Productos Naturales Vegetales, Departamento de Química, Universidad Nacional de Colombia, Bogotá, Colombia
Cuca L.E.:
Grupo de Investigación en Productos Naturales Vegetales, Departamento de Química, Universidad Nacional de Colombia, Bogotá, Colombia
Delgado G.:
Grupo de Investigación en Inmunotoxicología, Departamento de Farmacia, Universidad Nacional de Colombia, 3165120 Bogotá, Colombia
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