Pathogenesis of the idiopathic inflammatory myopathies [Patogenia de las miopatías inflamatorias idiopáticas]
Por:
Riebeling-Navarro C., Nava A.
Publicada:
1 ene 2009
Categoría:
Rheumatology
Resumen:
The inflammatory myopathies, commonly described as idiopathic, are a group of acquired diseases characterized by an inflammatory infiltrate of the skeletal muscle. On the basis of clinical and immuno-pathological features, three major diseases can be identified: dermatomiositis (DM), polymyositis (PM) and inclusion body myositis (IBM). Immunopathogenesis mechanisms are crucial for discriminating between the three different subsets of inflammatory myopathies. DM is a complement-mediated microangiopathy affecting skin and muscle. PM and IBM are T cell-mediated disorders, where CD8-positive cytotoxic T cells invade muscle fibres expressing MHC class I antigens. This article summarizes the main immunopathological markers. The impact of this new knowledge must be defined in relation to potential therapeutic targets for idiopathic inflammatory myopathies. © 2009 Elsevier España, S.L. All rights reserved.
Filiaciones:
Riebeling-Navarro C.:
Unidad de Investigación en Epidemiología Clínica, la UMAE HP CMNS-XXI, Instituto Mexicano del Seguro Social, México D.F., Mexico
Facultad de Medicina, Universidad Nacional Autónoma de México, México D. F., Mexico
Nava A.:
Departamento de Inmunología y Reumatología, Hospital General de Occidente, Secretaría de Salud, Guadalajara, Jalisco, Mexico
Unidad de Investigación en Epidemiología Clínica, la UMAE HE CMNO, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
Departamento de Investigación Ciencias de la Salud, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, Mexico
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