The reducible complexity of a mitochondrial molecular machine
Por:
Clements A., Bursac D., Gatsos X., Perry A.J., Civciristov S., Celik N., Likic V.A., Poggio S., Jacobs-Wagner C., Strugnell R.A., Lithgow T.
Publicada:
1 ene 2009
Categoría:
Multidisciplinary
Resumen:
Molecular machines drive essential biological processes, with the component parts of these machines each contributing a partial function or structural element. Mitochondria are organelles of eukaryotic cells, and depend for their biogenesis on a set of molecular machines for protein transport. How these molecular machines evolved is a fundamental question. Mitochondria were derived from an ?-proteobacterial endosymbiont, and we identified in ?-proteobacteria the component parts of a mitochondrial protein transport machine. In bacteria, the components are found in the inner membrane, topologically equivalent to the mitochondrial proteins. Although the bacterial proteins function in simple assemblies, relatively little mutation would be required to convert them to function as a protein transport machine. This analysis of protein transport provides a blueprint for the evolution of cellular machinery in general.
Filiaciones:
Clements A.:
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Bursac D.:
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia
Gatsos X.:
Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia
Perry A.J.:
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Civciristov S.:
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia
Celik N.:
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Likic V.A.:
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
Poggio S.:
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, United States
Jacobs-Wagner C.:
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, United States
Howard Hughes Medical Institute, New Haven, CT 06520, United States
Strugnell R.A.:
Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
Lithgow T.:
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Bronze
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