Adrenocortical carcinoma: A single institution experience
Por:
Gomez-Rivera F., Medina-Franco H., Arch-Ferrer J.E., Heslin M.J.
Publicada:
1 ene 2005
Resumen:
Adrenocortical carcinoma (ADCC) ranks among the least common malignant endocrine tumors. Surgical resection is considered the most important treatment for this neoplasm. Medical records of patients with the diagnosis of ADCC between 1990 and 2000 were reviewed. Patient and pathologic factors were analyzed with overall survival as the primary endpoint. Statistical analysis was performed by the method of Kaplan-Meier. There were a total of 17 patients, with a mean age of 56 years. Twelve per cent presented as an asymptomatic mass, 41 per cent as a functional tumor, and 47 per cent as a nonfunctioning tumor. Primary treatment was surgical resection in 71 per cent. There was no operative mortality and one complication. Seven patients presented with stage II, five with stage III, four with stage IV, and in one could not be determined. Median follow-up was 12.8 months, median survival 67, 13, and 3 months for stages II, III, and IV, respectively. Older age, distant metastasis, nonoperative management, positive margins, advanced tumor stage, and venous invasion were significantly associated with worse overall actuarial survival. Survival for ADCC is poor. Factors associated with a worse prognosis were stage of disease, nonoperative management, positive surgical margins, vascular invasion, and older age.
Filiaciones:
Gomez-Rivera F.:
Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States
Medina-Franco H.:
Division of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico
Arch-Ferrer J.E.:
Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States
Heslin M.J.:
Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States
University of Alabama at Birmingham, Department of Surgery, Section of Surgical Oncology, 1922 7th Avenue South, Birmingham, AL 35294, United States
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