Trypanosoma cruzi-associated cerebrovascular disease: A case-control study in Eastern Colombia
Por:
Leon-Sarmiento F.E., Mendoza E., Torres-Hillera M., Pinto N., Prada A J., Silva C.A., Vera C S.J., Castillo E., Valderrama V., Prada D.G., Bayona-Prieto J., Garcia I.
Publicada:
1 ene 2004
Resumen:
Trypanosoma cruzi infection is a common cause of cardiopathy in South America leading it eventually to an established stroke; however, the association between T. cruzi infection itself and cerebrovascular disease is still unknown. We did a case-control study at Eastern Colombia and found that T. cruzi infection was more frequent and statistically significant in stroke cases (24.4%) than controls (1.9%), (Chi square: 21.72; OR: 16.13; 95% confidence interval (CI): 3.64-71.4; p<0.00001). After removing the seropositive patients with cardiological abnormalities, the significance still remained by multivariate analysis (p<0.05). This is the first case-control study that demonstrated a significant link between this infection and symptomatic cerebrovascular disease, mainly ischemic, regardless of cardiac abnormalities. Therefore, we recommend that patients with stroke must be screened for T. cruzi infection if they currently live or have lived in places where this parasite is considered endemic. © 2003 Elsevier B.V. All rights reserved.
Filiaciones:
Leon-Sarmiento F.E.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Universidad de Pamplona, Pamplona, Norte de Santander, Colombia
Neuro.net-Inst. Colombiano N., Neurobiología Humana, Neurologia Clinica y Funcional, Bucaramanga, Colombia
Medical Neurology Branch, National Institutes of Health, NINDS, 10 Center Drive, Bethesda, MD 20892, United States
Mendoza E.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Torres-Hillera M.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Neuro.net-Inst. Colombiano N., Neurobiología Humana, Neurologia Clinica y Funcional, Bucaramanga, Colombia
Univ. Francisco de Paula Santander, Cucuta, Colombia
Pinto N.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Neuro.net-Inst. Colombiano N., Neurobiología Humana, Neurologia Clinica y Funcional, Bucaramanga, Colombia
Prada A J.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Silva C.A.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Vera C S.J.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Castillo E.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Valderrama V.:
Pontificia Universidad Javeriana, Bogotá, Colombia
Prada D.G.:
UIS-Santander University, School of Medicine, Bucaramanga, Colombia
Neuro.net-Inst. Colombiano N., Neurobiología Humana, Neurologia Clinica y Funcional, Bucaramanga, Colombia
Bayona-Prieto J.:
Universidad de Pamplona, Pamplona, Norte de Santander, Colombia
Neuro.net-Inst. Colombiano N., Neurobiología Humana, Neurologia Clinica y Funcional, Bucaramanga, Colombia
Garcia I.:
Instituto Nacional de Salud, Bogotá, Colombia
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