Interaction between Fe(II) and 1-4,dihydroxyanthraquinone: An spectroscopic and electrochemical study
Por:
González I., Morales A., González F., Moya R., Gómez M.
Publicada:
1 ene 2007
Resumen:
The 1,4 dihydroxyanthraquinone is a part of some antineoplasic drugs structure, these drugs interact directly with DNA. Daunomicine-DNA complexes can be stabilized by hydrogen bonding interactions, the anthraquinone structure remains intact and toxic effects come from its reduction to semiquinone. In order to diminish the daunomicine adverse effects, it is mixed with metallic ions, mainly Fe(II). The UV-vis spectrophotometric study proves the Fe(II) coordination by the 1-4, dihydroxyanthraquinone through the oxygen atoms from the carbonyl and phenyl groups, to produced a 1:1 complex ([Fe(II)H 2Q]), leaving the other phenyl group as hydrogen bonding donor. The electrochemical reduction process for the produced complex becomes complicated due to its characteristics: it shows not only charge transference but also proton transfer processes. The [Fe(II)H2Q] complex presents three different reduction process where a quinone radical species is produced for each one and every species differ in the number of hydrogen atoms. copyright The Electrochemical Society.
Filiaciones:
González I.:
Department of Chemistry, UAM-Iztapalapa, Mexico D.F. 09340, Mexico
Morales A.:
Department of Chemistry, FES-Cuautitlan UNAM, Edo de Mexico 54700, Mexico
González F.:
Department of Chemistry, CINVESTAV-IPN, Mexico D.F. 07360, Mexico
Moya R.:
Department of Chemistry, FES-Cuautitlan UNAM, Edo de Mexico 54700, Mexico
Gómez M.:
Department of Biological Systems, UAM-Xochimilco, Mexico D.F. 04960, Mexico
|