Combined drug design of potential Mycobacterium tuberculosis and HIV-1 inhibitors: 3',4'-di-substituted -4'H-spiro [isothiochromene-3,5'-isoxazol]-4(1H)-one
Por:
Bennani B., Kerbal A., Daoudi M., Filali Baba B., Al Houari G., Jalbout A.F., Mimouni M., Benazza M., Demailly G., Akkurt M., Öztürk Yildirim S., Ben Hadda T.
Publicada:
1 ene 2007
Resumen:
We report herein the design and synthesis of 17 new spiroheterocycles 10-26, on the basis of two hypothetical pharmacophore structures designed to interact with both of Mycobacterium tuberculosis bacteria and HIV-1 virus. The in vitro biological evaluation of these compounds allowed us to point out seven new potential non-nucleoside hits, with MIC values in the range of 6.25 ?g/mL and two new potential anti-HIV-1 inhibitors. ©ARKAT USA, Inc.
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