Low-Potential Cyclometalated Osmium(II) Mediators of Glucose Oxidase
Por:
Ryabov A.D., Soukharev V.S., Alexandrova L., Le Lagadec R., Pfeffer M.
Publicada:
1 ene 2003
Resumen:
The osma(II)cycles [Os(phpy)(LL)2]PF6 (LL = 1, 10-phen (3a) and 4,4?-Me2-2,2?-bpy (3b)) are made from [(?6-C6H6)Os(?-Cl)Cl]2 (1) either via transmetalation using the [Hg(phpy)2] organomercurial in MeOH or via the sp2-C-H bond cleavage of 2-phenylpyridine (phpyH) in MeCN to afford [(?6-C6H6)Os(phpy)Cl] or [(? 6-C6H6)-Os(phpy)(MeCN)]PF6, respectively. The latter two react cleanly with LL to give 3a and 3b, the M II/III redox potentials of which equal 30 and -100 mV (vs Ag/AgCl), respectively. The electrochemically made OsIII species oxidize rapidly reduced glucose oxidase. The second-order rate constant equals 1.1 × 107 M-1 s-1 for 3a at 25 °C, pH 7.
Filiaciones:
Ryabov A.D.:
Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, United States
Soukharev V.S.:
Division of Chemistry, G. V. PlekhanoV Russian Economic Academy, Stremyanny per. 28, 113054, Moscow, Russian Federation
Alexandrova L.:
IIM and Instituto de Química, UNAM, Circuito Exterior s/n, Ciudad Universitaria, Postal 70-360, Apartado, D.F., 04510, Mexico
Le Lagadec R.:
IIM and Instituto de Química, UNAM, Circuito Exterior s/n, Ciudad Universitaria, Postal 70-360, Apartado, D.F., 04510, Mexico
Pfeffer M.:
Laboratoire de Synthèses Métallo-Induites, UMR CNRS 7513, Université Louis Pasteur 4, rue Blaise Pascal 67070 Strasbourg, France
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