Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats
Por:
Cruz C., Correa-Rotter R., Sánchez-González D.J., Hernández-Pando R., Maldonado P.D., Martínez-Martínez C.M., Medina-Campos O.N., Tapia E., Aguilar D., Chirino Y.I., Pedraza-Chaverri J.
Publicada:
1 ene 2007
Resumen:
Progressive renal damage and hypertension are associated with oxidative and nitrosative stress. On the other hand, S-allylcysteine (SAC), the most abundant organosulfur compound in aged garlic extract (AG), has antioxidant properties. The effects of SAC and AG on blood pressure, renal damage, and oxidative and nitrosative stress were studied in five-sixths nephrectomized rats treated with SAC (200 mg/kg ip) and AG (1.2 ml/kg ip) every other day for 30 days. Proteinuria and serum creatinine and blood urea nitrogen concentrations were measured on days 0, 5, 10, 15, and 30, and systolic blood pressure was recorded on days 0, 15, and 30. The degree of glomerulosclerosis and tubulointerstitial damage, the immunostaining for inducible nitric oxide synthase, 3-nitrotyrosine, poly(ADP-ribose), and the subunits of NADPH oxidase p22phox and gp91phox, and the activity of SOD were determined on day 30. SAC and AG reduced hypertension, renal damage, and the abundance of inducible nitric oxide synthase, 3-nitrotyrosine, poly(ADP-ribose), p22phox, and gp91phox and increased SOD activity. Our data suggest that the antihypertensive and renoprotective effects of SAC and AG are associated with their antioxidant properties and that they may be used to ameliorate hypertension and delay the progression of renal damage. Copyright © 2007 the American Physiological Society.
Filiaciones:
Cruz C.:
Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Correa-Rotter R.:
Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Sánchez-González D.J.:
Departamento de Biología Celular, Escuela Médico Militar, Universidad del Ejército y Fuerza Aérea, Mexico City, Mexico
Hernández-Pando R.:
Departamento de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico
Maldonado P.D.:
Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología Y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
Martínez-Martínez C.M.:
Departamento de Biología Celular, Escuela Médico Militar, Universidad del Ejército y Fuerza Aérea, Mexico City, Mexico
Medina-Campos O.N.:
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, México City, Mexico
Tapia E.:
Departamento de Nefrología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Aguilar D.:
Departamento de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico
Chirino Y.I.:
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, México City, Mexico
Pedraza-Chaverri J.:
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, México City, Mexico
Facultad de Química, Departamento de Biología, Ciudad Universitaria, 04510, Mexico DF, Mexico
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