Rotavirus diarrhea severity is related to the VP4 type in Mexican children
Por:
Mota-Hernández F., José Calva J., Gutiérrez-Camacho C., Villa-Contreras S., Arias C.F., Padilla-Noriega L., Guiscafré-Gallardo H., De Lourdes Guerrero M., López S., Muñoz O., Contreras J.F., Cedillo R., Herrera I., Puerto F.I.
Publicada:
1 ene 2003
Resumen:
This report is of a community-based case control study to assess whether the severity of acute diarrhea by rotavirus (RV) in young children is associated with a particular VP7 (G) or VP4 (P) RV serotype. Five hundred twenty children younger than 2 years of age with diarrhea lasting less than 3 days were age and gender matched with 520 children with no diarrhea. The G and P serotypes were determined with specific monoclonal antibodies, and the VP4 serotype specificity in a subgroup was confirmed by genotyping. Infection with a G3 serotype led to a higher risk of diarrhea than infection with a G1 serotype. Infection with a G3-nontypeable-P serotype was associated with more severe gastroenteritis than infection with a G3 (or G1) P1A[8] serotype. A child with diarrhea-associated dehydration was almost five times more likely to be infected with a G3-nontypeable-P serotype than a child without dehydration (P < 0.001). Moreover, the two predominant monotypes within serotype P1A[8] had significantly different clinical manifestations. In this study, the severity of RV-associated diarrhea was related to different P serotypes rather than to G serotypes. The relationship between serotype and clinical outcomes seems to be complex and to vary among different geographic areas.
Filiaciones:
Mota-Hernández F.:
Depto. de Med. Comunitaria en H. O., Hosp. Inf. de Mex. Federico Gomez, Mexico City, Mexico
Depto. de Invest. en Med. C./H. O., Hosp. Inf. de Mexico Federico Gomez, Calle Dr. Márquez 162, Mexico City 06720, Mexico
José Calva J.:
Inst. Nac. C. M./N. Salvador Zubiran, Mexico City, Mexico
Gutiérrez-Camacho C.:
Depto. de Med. Comunitaria en H. O., Hosp. Inf. de Mex. Federico Gomez, Mexico City, Mexico
Villa-Contreras S.:
Instituto Mexicano del Seguro Social, Mexico City, Mexico
Arias C.F.:
Instituto de Biotecnologia, Univ. Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
Padilla-Noriega L.:
Instituto de Biotecnologia, Univ. Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
Inst. de Investigaciones Biomedicas, Univ. Nacional Autonoma de Mexico, Mexico City, Mexico
Guiscafré-Gallardo H.:
Instituto Mexicano del Seguro Social, Mexico City, Mexico
De Lourdes Guerrero M.:
Inst. Nac. C. M./N. Salvador Zubiran, Mexico City, Mexico
López S.:
Instituto de Biotecnologia, Univ. Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
Muñoz O.:
Instituto Mexicano del Seguro Social, Mexico City, Mexico
Contreras J.F.:
Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Monterrey Nuevo León, Mexico
Cedillo R.:
Instituto Mexicano del Seguro Social, Mexico City, Mexico
Herrera I.:
Facultad de Medicina, Univ. Autonoma de S. Luis Potosi, San Luis Potosi, Mexico
Puerto F.I.:
Ctro. de Invest. R. Hideyo Noguchi, Universidad Autonoma de Yucatan, Mérida, Yucatán, Mexico
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