Cytokine induction of prolactin receptors mediates prolactin inhibition of nitric oxide synthesis in pulmonary fibroblasts
Por:
Corbacho A.M., Macotela Y., Nava G., Eiserich J.P., Cross C.E., Martínez De La Escalera G., Clapp C.
Publicada:
1 ene 2003
Resumen:
Prolactin (PRL) has been implicated as a modulator of immune function, and some of its actions may be linked to NO synthesis. Because NO acts as a mediator of inflammation, we speculated that an inflammatory milieu could unmask pathways by which PRL could affect NO synthesis. Here, we show that pro-inflammatory cytokines induce the expression of PRL receptors in pulmonary fibroblasts, allowing PRL to inhibit cytokine-induced NO production and the expression of the inducible nitric oxide synthase (iNOS). Inhibition of iNOS expression by PRL correlates with the phosphorylation of STAT-5b (signal transducer and activator of transcription 5b) and the suppression of expression of IRF-1 (interferon regulatory factor 1), a transcription factor for iNOS. These results reveal previously unrecognized mechanisms by which PRL and PRL receptors may play significant modulatory roles during immune-inflammatory processes. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Filiaciones:
Corbacho A.M.:
Instituto de Neurobiología, Univ. Nac. Auton. de Mex., Campus UNAM-Juriquilla, Apartado Postal 1-1141, Juriquilla-Queretaro, Qro. 76001, Mexico
Divisions Pulmon./Critical Care M., Department of Internal Medicine, University of California at Davis, Davis, CA 95616, United States
Macotela Y.:
Instituto de Neurobiología, Univ. Nac. Auton. de Mex., Campus UNAM-Juriquilla, Apartado Postal 1-1141, Juriquilla-Queretaro, Qro. 76001, Mexico
Nava G.:
Instituto de Neurobiología, Univ. Nac. Auton. de Mex., Campus UNAM-Juriquilla, Apartado Postal 1-1141, Juriquilla-Queretaro, Qro. 76001, Mexico
Eiserich J.P.:
Divisions Pulmon./Critical Care M., Department of Internal Medicine, University of California at Davis, Davis, CA 95616, United States
Cross C.E.:
Divisions Pulmon./Critical Care M., Department of Internal Medicine, University of California at Davis, Davis, CA 95616, United States
Martínez De La Escalera G.:
Instituto de Neurobiología, Univ. Nac. Auton. de Mex., Campus UNAM-Juriquilla, Apartado Postal 1-1141, Juriquilla-Queretaro, Qro. 76001, Mexico
Clapp C.:
Instituto de Neurobiología, Univ. Nac. Auton. de Mex., Campus UNAM-Juriquilla, Apartado Postal 1-1141, Juriquilla-Queretaro, Qro. 76001, Mexico
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