The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: Association with obesity and obesity-related comorbidities
Por:
Villarreal-Molina M.T., Aguilar-Salinas C.A., Rodríguez-Cruz M., Riaño D., Villalobos-Comparan M., Coral-Vazquez R., Menjivar M., Yescas-Gomez P., Königsoerg-Fainstein M., Romero-Hidalgo S., Tusie-Luna M.T., Canizales-Quinteros S., Flores-Dorantes M.T., Guerra-Garcia M.T., Huertas-Vazquez A., Rosales-Escamilla A., Cruz-Bautista I., Gomez-Perez F., Ortiz-Lopez G., Brito-Zurita O., Noguchi H., Cetina T.C.-D.
Publicada:
1 ene 2007
Resumen:
Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions. Because hypoalphalipoproteinemia is highly prevalent in Mexico, we screened the ABCA1 coding sequence in Mexican individuals with low and high HDL cholesterol levels to seek functional variants. A highly frequent nonsynonymous variant (R230C) was identified in low-HDL cholesterol but not in high-HDL cholesterol individuals (P = 0.00006). We thus assessed its frequency in the Mexican-Mestizo general population, seeking possible associations with several metabolic traits. R230C was screened in 429 Mexican Mestizos using Taqman assays, and it was found in 20.1% of these individuals. The variant was significantly associated not only with decreased HDL cholesterol and apolipoprotein A-I levels but also with obesity (odds ratio 2.527, P = 0.005), the metabolic syndrome (1.893, P = 0.0007), and type 2 diabetes (4.527, P = 0.003). All of these associations remained significant after adjusting for admixture (P = 0.011, P = 0.001, and P = 0.006, respectively). This is the first study reporting the association of an ABCA1 variant with obesity and obesity-related comorbidities as being epidemiologically relevant in the Mexican population. © 2007 by the American Diabetes Association.
Filiaciones:
Villarreal-Molina M.T.:
Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition (INCMNSZ), National Autonomous University of Mexico, Mexico City, Mexico
PhD Program in Experimental Biology, Autonomous Metropolitan University, Mexico City, Mexico
Aguilar-Salinas C.A.:
Department of Endocrinology and Metabolism, INCMNSZ, National Autonomous University of Mexico, Mexico City, Mexico
Rodríguez-Cruz M.:
Unit of Medical Research in Nutrition, Pediatrics Hospital, Mexican Institute of Social Security, Mexico City, Mexico
Riaño D.:
Department of Endocrinology and Metabolism, INCMNSZ, National Autonomous University of Mexico, Mexico City, Mexico
Villalobos-Comparan M.:
Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition (INCMNSZ), National Autonomous University of Mexico, Mexico City, Mexico
Coral-Vazquez R.:
Unit of Medical Research in Human Genetics, Pediatrics Hospital, Mexican Institute of Social Security, Mexico City, Mexico
Menjivar M.:
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City, Mexico
Yescas-Gomez P.:
Department of Geriatrics, Manuel Velasco Suarez National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Königsoerg-Fainstein M.:
Division of Health and Biological Sciences, Autonomous Metropolitan University-Iztapalapa, Mexico City, Mexico
Romero-Hidalgo S.:
National Coordination of Genetic Medicine, Institute of Social Security and Services for Government Employees, Mexico City, Mexico
Tusie-Luna M.T.:
Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition (INCMNSZ), National Autonomous University of Mexico, Mexico City, Mexico
Canizales-Quinteros S.:
Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition (INCMNSZ), National Autonomous University of Mexico, Mexico City, Mexico
Unidad de Biología Molecular Y Medicina Genómica, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, V. de Quiroga #15 Colonia Secc. 16, Tlalpan 14000, México D.F., Mexico
Flores-Dorantes M.T.:
Unit of Molecular Biology and Genomic Medicine, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico
Guerra-Garcia M.T.:
Unit of Molecular Biology and Genomic Medicine, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico
Huertas-Vazquez A.:
Unit of Molecular Biology and Genomic Medicine, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico
Rosales-Escamilla A.:
Department of Endocrinology and Metabolism, INCMNSZ, Mexico City, Mexico
Cruz-Bautista I.:
Department of Endocrinology and Metabolism, INCMNSZ, Mexico City, Mexico
Gomez-Perez F.:
Department of Endocrinology and Metabolism, INCMNSZ, Mexico City, Mexico
Ortiz-Lopez G.:
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City, Mexico
Brito-Zurita O.:
Unit of Medical Research in Clinical Epidemiology, Hospital de Especialidades No. 2, CMNNO, Ciudad Obregón, Sonora, Mexico
Noguchi H.:
Laboratory of Reproductive Biology, Centro de Investigaciones Regionales
Cetina T.C.-D.:
Autonomous University of Yucatán, Yucatan, Mexico
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