Characterization of sodium phenytoin co-gelled with titania for a controlled drug-release system


Por: López T., Quintana P., Ortiz-Islas E., Vinogradova E., Manjarrez J., Aguilar D.H., Castillo-Ocampo P., Magaña C., Azamar J.A.

Publicada: 1 ene 2007
Resumen:
Sodium phenytoin, C15H11N2NaO2, in several concentrations was co-gelled with titania (TiO2), by a sol-gel process. This technique is a promising method to encapsulate several drugs, in this case, phenytoin is an anticonvulsant used to control epileptic seizures. Samples were prepared by adding different concentrations (X = 50, 100, 200 and 250 mg per 20 g of titania matrix) of sodium phenytoin (Ph) to a solution of titanium n-butoxide. The resulting titania-Ph-X materials were characterized by transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and Brunauer-Emmet-Teller (BET) surface areas. The porous nanomaterials showed a wide range of particle size, from 10 to 210 nm, with a mean pore diameter of 5 nm. X-ray diffraction showed an amorphous structure of the prepared samples. © 2006 Elsevier Inc. All rights reserved.

Filiaciones:
López T.:
 Universidad Autonoma Metropolitana-Iztapalapa, Department of Chemistry, P.O. Box 55-534, México 09340 D. F., Mexico

 Instituto Nacional de Neurología y Neurocirugía MVS, Av.Insurgentes Sur 3877.Col.La Fama., PO Box 14269 México D. F., Mexico

Quintana P.:
 Cinvestav-I.P.N. Unidad Merida. Applied Physics Department, P.O. Box. 73, Cordemex, 97310 Merida, Yucatan, Mexico

Ortiz-Islas E.:
 Universidad Autonoma Metropolitana-Iztapalapa, Department of Chemistry, P.O. Box 55-534, México 09340 D. F., Mexico

Vinogradova E.:
 Universidad Autonoma Metropolitana-Iztapalapa, Department of Chemistry, P.O. Box 55-534, México 09340 D. F., Mexico

Manjarrez J.:
 Instituto Nacional de Neurología y Neurocirugía MVS, Av.Insurgentes Sur 3877.Col.La Fama., PO Box 14269 México D. F., Mexico

Aguilar D.H.:
 Cinvestav-I.P.N. Unidad Merida. Applied Physics Department, P.O. Box. 73, Cordemex, 97310 Merida, Yucatan, Mexico

Castillo-Ocampo P.:
 Universidad Autonoma Metropolitana-Iztapalapa, Department of Chemistry, P.O. Box 55-534, México 09340 D. F., Mexico

Magaña C.:
 Physics Institute, UNAM, Circuito de la Investigacion, s/n, Mex. D.F., Mexico

Azamar J.A.:
 Cinvestav-I.P.N. Unidad Merida. Applied Physics Department, P.O. Box. 73, Cordemex, 97310 Merida, Yucatan, Mexico
ISSN: 10445803
Editorial
Elsevier Inc., 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 58 Número: 8-9
Páginas: 823-828
WOS Id: 000248435800026