Küttner's tumour (chronic sclerosing sialadenitis). Clinical, pathological, and immunohistochemical study in 8 cases of a little-known entity [Tumor de Küttner (sialoadenitis crónica esclerosante). Estudio clinicopatológico e inmunohisto
Por:
Consuegra N.M., Heredia J.B., Cisneros R.S., Rocha M.L.M., Ortiz-Hidalgo C.
Publicada:
1 ene 2007
Categoría:
Otorhinolaryngology
Resumen:
Objective: To present the clinical-pathological characteristics of Küttner's tumour (KT) or chronic sclerosing sialadenitis. Material and method: We studied 8 cases of KT that were graduated histologically according to the Seifert grading system. An immunohistochemistry panel including CD20, CD3, and keratin AE1-3 was performed. Results: All cases involved the sub-maxillary gland. Microscopically the cases were in stages 2, 3, and 4. There was a chronic inflammatory infiltrate, marked fibrosis, variable degrees of parenchymal atrophy, PAS+ intraluminal material, and microliths. The infiltrate was polymorphic and polyclonal, without lymphoepithelial lesions. Conclusions: Although it has a typical clinical and pathological presentation and was described more than a century ago, KT remains under-diagnosed and often reported as non-specific inflammatory infiltrate or as "low grade lymphoma". In this latter diagnosis lies the greatest importance for recognizing KT, as confusion with lymphoma would result in a different therapeutic approach.
Filiaciones:
Consuegra N.M.:
Departamento de Patología, Centro Médico ABC, México DF, Mexico
Heredia J.B.:
Departamento de Patología, Centro Médico ABC, México DF, Mexico
Cisneros R.S.:
Departamento de Patología, Centro Médico Nacional 20 de Noviembre, ISSSTE, México DF, Mexico
Rocha M.L.M.:
Departamento de Patología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México DF, Mexico
Ortiz-Hidalgo C.:
Departamento de Patología, Centro Médico ABC, México DF, Mexico
Departamento de Biología Celular Y Tisular, Universidad Panamericana, México DF, Mexico
Departamento de Patología, Centro Médico ABC, Sur 136#116 Las Américas, México DF 01120, Mexico
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