A Fokker-Planck framework in the PolyC:PolyG denaturation
Por:
Resendis-Antonio O.
Publicada:
1 ene 2002
Resumen:
In this work the author presents a Fokker-Planck formalism to describe the denaturation process for simple DNA chains as PolyC:PolyG. This model consists in simulating the denaturation as a diffusion process of a virtual particle moving in an effective external potential. Assuming that such potential is harmonic, we obtain the melting temperature for a PolyC:PolyG chain. Under this assumption the melting temperature Tm, becomes a function of two parameters which specify the nature of the effective potential. The values of the parameters which lead to an agreement between the experimental and theoretical melting temperatures for a PolyC:PolyG chain immersed in a solution of 19.5 mM of Na+ and pH 7 are reported. © 2002 Elsevier Science B.V. All rights reserved.
Filiaciones:
Resendis-Antonio O.:
Departamento De Fisica, Universidad Autónoma Metropolitana-Iztapalapa, 09340, México, D.F., Mexico
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