Non-optimal levels of dietary selenomethionine alter splenocyte response and modify oxidative stress markers in female mice
Por:
Vega L., Rodríguez-Sosa M., García-Montalvo E.A., Del Razo L.M., Elizondo G.
Publicada:
1 ene 2007
Resumen:
Many studies evaluating the effects of selenium (Se) status on immunity utilize inorganic Se, although selenomethionine (Se-Met) has been suggested to be more bioavailable and less toxic. In the current study, we investigated the effects of dietary Se-Met on immune system function and cellular redox status in C57BL/6N female mice fed with low (0.02 ppm), sufficient (0.2 ppm, control group), or excess Se-Met (2 ppm) in the diet for 50 days. Low Se-Met intake reduced glutathione peroxidase (GPx) activity and glutathione concentration without modifying lipoperoxidation. While low Se-Met intake also reduced the number of B cells in the spleen, it increased mitogen-induced proliferation, IL-4 and IL-12 secretion when compared to the sufficient Se-Met intake group. In comparison to controls, excess Se-Met intake increased splenocyte proliferation and reduced B cell numbers, IL-4, and IL-12 secretion without affecting oxidative stress markers. These data suggest that Se-Met supplementation should be carefully evaluated as it many influence immune function. © 2007 Elsevier Ltd. All rights reserved.
Filiaciones:
Vega L.:
Sección Externa de Toxicología, Centro de Investigación y de Estudios Avanzados, Av. IPN 2508, San Pedro Zacatenco, Mexico DF 07360, Mexico
Rodríguez-Sosa M.:
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, UNAM, Estado de México 54090, Mexico
García-Montalvo E.A.:
Sección Externa de Toxicología, Centro de Investigación y de Estudios Avanzados, Av. IPN 2508, San Pedro Zacatenco, Mexico DF 07360, Mexico
Del Razo L.M.:
Sección Externa de Toxicología, Centro de Investigación y de Estudios Avanzados, Av. IPN 2508, San Pedro Zacatenco, Mexico DF 07360, Mexico
Elizondo G.:
Sección Externa de Toxicología, Centro de Investigación y de Estudios Avanzados, Av. IPN 2508, San Pedro Zacatenco, Mexico DF 07360, Mexico
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