Ionic basis of pharmacological therapy in Brugada syndrome
Por:
Márquez M.F., Salica G., Hermosillo A.G., Pastelín G., Gómez-Flores J., Nava S., Cárdenas M.
Publicada:
1 ene 2007
Resumen:
Pharmacotherapy of Brugada syndrome. An implantable cardioverter- defibrillator is considered the only effective therapy to terminate ventricular arrhythmias in symptomatic patients with Brugada syndrome. However, it does not prevent future arrhythmic episodes. Only antiarrhythmic drug therapy can prevent them. There have been several reports of a beneficial effect of oral quinidine in both asymptomatic and symptomatic patients. Other possible beneficial oral agents could be Ito blockers. Intravenous isoproterenol has been reported to be especially useful in abolishing arrhythmic storms in emergency situations. Also, isolated case reports on the usefulness of cilostazol, sotalol, and mexiletine have been described. The present article reviews the mechanisms by which these drugs may act and their possible role in the pharmacotherapy of this disease. © 2007 by Futura Publishing Company, Inc.
Filiaciones:
Márquez M.F.:
Department of Electrocardiology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Electrocardiología, Juan Badiano 1, Tlalpan 14080, México, D.F., Mexico
Salica G.:
Department of Electrocardiology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Hermosillo A.G.:
Department of Electrocardiology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Pastelín G.:
Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Gómez-Flores J.:
Department of Electrocardiology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Nava S.:
Department of Electrocardiology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
Cárdenas M.:
Department of Electrocardiology, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico
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