NO donor SIN-I potentiates monosynaptic reflexes in the cat spinal cord
Por:
Manjarrez E., Rocha T., Rojas-Piloni G., Méndez I., Vélez D., Flores A.
Publicada:
1 ene 2001
Resumen:
The effect produced by the nitric oxide donor SIN-I on monosynaptic reflexes was examined. Experiments were performed on anesthetized, paralyzed and spinalized cats. Lumbar monosynaptic reflexes were produced by stimulation of Ia afferents. I.v. application of SIN-I (500 ?g/kg) produced a mean marked potentiation of 704% of pre-drug control (100%) in the amplitude of monosynaptic reflexes. In addition, in other experiments a concentration-dependent effect on the amplitude of monosynaptic reflexes was observed after microinjections of SIN-I into the ventral horn (1 ?l; 10-12-10-3 M), with a mean facilitatory effect of 355%. In both cases, the potentiation was reversible 45 min after i.v. or local application of SIN-I. These results provide the first evidence that monosynaptic reflexes can be potentiated by nitric oxide. © 2001 Lippincott Williams & Wilkins.
Filiaciones:
Manjarrez E.:
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Col. San Manuel, Apartado Postal 406, Puebla, Pue. CP 72570, Mexico
Rocha T.:
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Col. San Manuel, Apartado Postal 406, Puebla, Pue. CP 72570, Mexico
Rojas-Piloni G.:
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Col. San Manuel, Apartado Postal 406, Puebla, Pue. CP 72570, Mexico
Méndez I.:
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Col. San Manuel, Apartado Postal 406, Puebla, Pue. CP 72570, Mexico
Vélez D.:
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Col. San Manuel, Apartado Postal 406, Puebla, Pue. CP 72570, Mexico
Flores A.:
Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Col. San Manuel, Apartado Postal 406, Puebla, Pue. CP 72570, Mexico
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