Fungal responses to reactive oxygen species


Por: Aguirre J., Hansberg W., Navarro R.

Publicada: 1 ene 2006
Resumen:
Reactive oxygen species (ROS) such as hydrogen peroxide, produced externally or during normal metabolism, can damage different cell components and usually trigger a counteracting antioxidant response. The fact that animals and humans utilize ROS and related nitrogen reactive species to prevent fungal infection has generated great interest in defining the components of the antioxidant response and studying their role as virulence determinants in fungi. Here we review the role of specific enzyme and non-enzyme mediated antioxidant mechanisms in virulence, as well as the signal transduction mechanisms that fungal cells use to perceive high ROS levels and induce gene expression. We focus on Schizosaccharomyces pombe antioxidant responses, which involve a prokaryotic-type multistep phosphorelay coupled to a stress-response MAP kinase pathway and an AP-1 type transcription factor, in relation to homologous mechanisms in Aspergillus nidulans and the human pathogen A. fumigatus. Compared to S. pombe and other unicellular fungi, filamentous fungi have additional mechanisms to handle ROS, such as the presence of a larger number of phosphorelay sensor kinases, antioxidant enzymes and secondary metabolites with antioxidant functions. In addition, filamentous fungi have enzymes like the NADPH oxidases, which regulate multicellular development through ROS production and therefore, offer a unique opportunity to study the interplay between ROS production, perception and detoxification, and the role of these processes in cell differentiation and pathogenesis.

Filiaciones:
Aguirre J.:
 Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, Mexico

Hansberg W.:
 Departamento de Bioquímica, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, Mexico

Navarro R.:
 Departamento de Biología Celular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, Mexico
ISSN: 13693786
Editorial
Informa Healthcare, 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 44 Número: SUPP
Páginas: 101-107
WOS Id: 000242601400019
ID de PubMed: 30408892
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