Phage displayed biomolecules as preventive and therapeutic agents


Por: Manoutcharian K., Gevorkian G., Cano A., Almagro J.C.

Publicada: 1 ene 2001
Resumen:
Phage display is a powerful technology for selecting and engineering peptides and proteins expressed on the surface of filamentous bacteriophage. The advantages of phage display technology over other research tools and its' great potential have been demonstrated by successful application of phage display in diverse fields of biomedical/clinical research. In this review we will describe some recent developments in phage display, including new expression vectors, display formats, bioselection strategies and applications in pharmaceutical biotechnology. We highlight some important applications of phage display to identify disease- and pathogen-specific biomolecules, making particular emphasis on development of phage display-derived preventive and therapeutic vaccines.

Filiaciones:
Manoutcharian K.:
 Instituto Investigaciones Biomedicas, Universidad Nacional Autonoma Mexico, Apartado Postal 70228, Mexico City 04510, Mexico

Gevorkian G.:
 Instituto Investigaciones Biomedicas, Universidad Nacional Autonoma Mexico, Apartado Postal 70228, Mexico City 04510, Mexico

Cano A.:
 Instituto Investigaciones Biomedicas, Universidad Nacional Autonoma Mexico, Apartado Postal 70228, Mexico City 04510, Mexico

Almagro J.C.:
 Instituto Investigaciones Biomedicas, Universidad Nacional Autonoma Mexico, Apartado Postal 70228, Mexico City 04510, Mexico
ISSN: 13892010
Editorial
BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES, Países Bajos
Tipo de documento: Article
Volumen: 2 Número: 3
Páginas: 217-223
ID de PubMed: 11530876

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