Estudio inmunogenético en parejas mexicanas con abortos esponta"neos recurrentes
Por:
Silva B., Yamamoto-Furusho J.K., Grether P., Vargas-Alarcón G., Kofman S., Granados J.
Publicada:
1 ene 1997
Resumen:
Aim. To study the HLA markers in Mexican couples who have suffered three or more spontaneous abortions. Design. The study included 24 couples with recurrent abortions and 32 with normal fertility. Method. HLA class I (A, B, C) and class II (DR, DQ) typing was done with a standard microlymphocitoxity test. The intergroup differences were evaluated by chi-square and the Fisher exact test. Results. The frequency of the MHC markers in the males and females of couples with abortions were not significantly different from those in fertile couples. However, the abortion couples shared class I antigens more often than expected from random mating as compared to fertile couples, specially in the HLA-B locus. We also found a significantly decreased frequency of the HLA-B7 antigen in males belonging to the abortion group. Conclusion. These results suggest that HLA-B antigens may be markers for genes related to pregnancy outcome in Mexicans.
Filiaciones:
Silva B.:
Departamento de Genética, Hosp. General de México, SS, Mexico
Yamamoto-Furusho J.K.:
Depar-tamento Inmunologia y R., Inst. Nac. la Nutr. Salvador Zubiran, Mexico
Grether P.:
Departamento de Genética, Inst. Nac. de Perinatología, Mexico
Vargas-Alarcón G.:
Depar-tamento Inmunologia y R., Inst. Nac. la Nutr. Salvador Zubiran, Mexico
Kofman S.:
Depar-tamento Inmunologia y R., Inst. Nac. la Nutr. Salvador Zubiran, Mexico
Granados J.:
Depar-tamento Inmunologia y R., Inst. Nac. la Nutr. Salvador Zubiran, Mexico
Depto. de Inmunologia y Reumatologia, Inst. Nac. la Nutr. Salvador Zubiran, Vasco de Quiroga 15, Tlalpan 14000, México, D.F., Mexico
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