Intrinsic sensing fluorescent probe for the solid phase synthesis of 1,4-benzodiazepine-2,5-dione
Por:
Rivero I.A., Peralta M., Heredia S., Madrigal D., Pina-Luis G., Chávez D.
Publicada:
1 ene 2003
Resumen:
The synthesis of 4-N-naphthylethyl-1,4-benzodiazepine-2,5-dione (1) supported on solid phase is described. The fluorescent naphthyl group is used as internal sensor for monitoring various stages on the synthetic reaction by spectral differences in fluorescence. Our results show the efficacy of fluorescence as a direct method for the evaluation of reaction progress. This method is fast, sensitive and non-destructive. A target molecule was synthesized which could be used in the synthesis of a variety of benzodiazepines.
Filiaciones:
Rivero I.A.:
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000 Tijuana, B. C., Mexico
Peralta M.:
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000 Tijuana, B. C., Mexico
Heredia S.:
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000 Tijuana, B. C., Mexico
Madrigal D.:
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000 Tijuana, B. C., Mexico
Pina-Luis G.:
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000 Tijuana, B. C., Mexico
Chávez D.:
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, 22000 Tijuana, B. C., Mexico
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