Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population
Por:
Herrera-Goepfert R., Akiba S., Koriyama C., Ding S., Reyes E., Itoh T., Minakami Y., Eizuru Y.
Publicada:
1 ene 2005
Resumen:
Aim: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC among a Mexican population. Methods: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of Pathology at the Instituto Nacional de Cancerología and the Instituto Nacional de la Nutrición in Mexico City. The anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1) in situ hybridization was conducted to determine the presence of EBV in neoplastic cells. Results: We studied 330 consecutive, non-selected primary gastric carcinomas. Among these, there were 173 male and 157 female patients (male/female ratio 1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/ female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively. Conclusion: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
Filiaciones:
Herrera-Goepfert R.:
Department of Pathology, Instituto Nacional de Cancerologia, Av. San Fernando 22, México, DF 14080, Mexico
Akiba S.:
Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Koriyama C.:
Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ding S.:
Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Reyes E.:
Department of Pathology, Instituto Nacional de Ciencias Médicas y de la Nutrición Salvador Zubiran, Mexico City, Mexico
Itoh T.:
Department of Pathology, Kagoshima Institute of Preventive Medicine, Kagoshima, Japan
Minakami Y.:
Division of Oncogenic and Persistent Viruses, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Eizuru Y.:
Division of Oncogenic and Persistent Viruses, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
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