Interaction between isoniazid and diverse vasodilators: Role of decreased cerebral GABA


Por: De Los Angeles Sánchez-Salvatori M., Ríos C., Vidrio H.

Publicada: 1 ene 1998
Resumen:
Objective: To determine if the interaction between isoniazid and hydralazine, consisting of increased hypotension accompanied by bradycardia, occurs with other vasodilators. Methods: Blood pressure and heart rate responses to a number of vasodilators were determined in rats under chloralose-urethane, pretreated or not with 250 mg/kg of isoniazid. The influence of this dose of isoniazid on GABA levels in the hypothalamus and pons-medulla was assessed in other groups of rats. Results: Increased hypotension and bradycardia following i.p. isoniazid were observed with dipyridamole, prazosin, pinacidil and hydralazine given i.v. Bradycardia without increased hypotension appeared with papaverine and verapamil, while increased hypotension with unchanged heart rate was observed with minoxidil and captopril. Isoniazid decreased GABA in the hypothalamus and pons-medulla. Conclusions: At the high dose used, isoniazid interacts with various vasodilators, irrespective of their mechanism of action. The interaction could be due to the influence of the drug on GABA levels at cardiovascular regulatory sites.

Filiaciones:
De Los Angeles Sánchez-Salvatori M.:
 Department of Pharmacology, School of Medicine, National University of Mexico, Mexico City, Mexico

Ríos C.:
 Department of Neurochemistry, Natl. Inst. of Neurol. and Neurology, Mexico City, Mexico

Vidrio H.:
 Department of Pharmacology, School of Medicine, National University of Mexico, Mexico City, Mexico
ISSN: 00086363
Editorial
OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 37 Número: 3
Páginas: 748-755
WOS Id: 000073838100024
ID de PubMed: 9659459
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