Antigens and antibodies in sera from human cases of epilepsy or taeniasis from an area of Mexico where Taenia solium cysticercosis is endemic
Por:
Correa D., Sarti E., Tapia-Romero R., Rico R., Alcántara-Anguiano I., Salgado A., Valdez L., Flisser A.
Publicada:
1 ene 1999
Resumen:
Human neurocysticercosis is an important parasitic disease in developing countries. Most epidemiological studies on the disease have used antibody-based assays that allow the detection of transmission 'hot spots' and the identification of the main risk factors for transmission. However, such assays have low predictive value in the detection of active cases of neurocysticercosis. The screening potential of the most commonly used antibody-detection technique, the electroimmunotransfer blot assay (EITB), has now been compared with an antigen-capture assay, in an endemic region of Mexico. The subjects were 68 patients with late-onset epilepsy, 35 cases of taeniasis and a randomly selected, control group of 133 individuals from the same region. Parasite-specific antibodies and antigens were more common among the epileptics and taeniasis cases than among the controls. The antigens appeared to be associated with late-onset epilepsy and the antibodies with the presence of subcutaneous nodules. The sensitivities of both tests, to detect epilepsy or taeniasis, were low, but the specificity and the positive predictive value of the antigen-capture assay was high when used with the epileptics. As late-onset epilepsy and neurocysticercosis seem to be associated in endemic regions, antigen-capture assays are probably the most reliable method of detecting active cases of neurocysticercosis in epidemiological studies.
Filiaciones:
Correa D.:
Inst. Nac. de Diagnostico y R., Secretaria de Salud, Carpio 470, Santo Tomas, Mexico 11340, DF, Mexico
Sarti E.:
Direccion General de Epidemiologia, Secretaria de Salud, México, DF, Mexico
Tapia-Romero R.:
Inst. Nac. de Diagnostico y R., Secretaria de Salud, Carpio 470, Santo Tomas, Mexico 11340, DF, Mexico
Rico R.:
Facultad de Medicina, Univ. Nacional Autonoma de Mexico, México, DF, Mexico
Alcántara-Anguiano I.:
Inst. Nac. de Diagnostico y R., Secretaria de Salud, Carpio 470, Santo Tomas, Mexico 11340, DF, Mexico
Salgado A.:
Facultad de Medicina, Univ. Nacional Autonoma de Mexico, México, DF, Mexico
Valdez L.:
Facultad de Medicina, Univ. Nacional Autonoma de Mexico, México, DF, Mexico
Flisser A.:
Inst. Nac. de Diagnostico y R., Secretaria de Salud, Carpio 470, Santo Tomas, Mexico 11340, DF, Mexico
Facultad de Medicina, Univ. Nacional Autonoma de Mexico, México, DF, Mexico
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