Estrogenic effects of p-Hydroxybenzoic acid in CD1 mice
Por:
Lemini C., Silva G., Timossi C., Luque D., Valverde A., González-Martínez M., Hernández A., Rubio-Póo C., Chávez Lara B., Valenzuela F.
Publicada:
1 ene 1997
Resumen:
Xenobiotic estrogens in the environment or diet have received much attention as a possible source of certain hormonal disease states in human and wildlife. Therefore, the detection of estrogenic activity of any substance, especially those related to the food industry, is important. The estrogenic activity of p-hydroxybenzoic acid (PHBA), a compound related to a commonly used group of preservatives in food, cosmetic, and pharmaceutical preparations, was evaluated with immature and adult ovariectomized female mice (CD1) using two well-known bioassays. Subcutaneous administrations (sc) of different doses of PHBA were compared with estradiol (E2), and their effects on vaginal cornification and uterotrophic activities were evaluated. Different groups of animals were treated sc daily for 3 days with vehicle (corn oil, 0.3 ml/100 g), E2 (1 ?g/100 g), and PHBA (0.5, 5, 50, and 500 ?g/100 g). Four days after treatment, PHBA produced a dose-dependent response on vaginal cornification and uterotrophic activity in both immature and adult ovariectomized mice. The relative uterotrophic potency of PHBA (500 ?g/100 g) to E2 (1 ?g/100 g) was 0.0011 in immature mice and 0.0018 in ovariectomized animals.
Filiaciones:
Lemini C.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Silva G.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Timossi C.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Luque D.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Valverde A.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
González-Martínez M.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Hernández A.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Rubio-Póo C.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Chávez Lara B.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
Valenzuela F.:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-297, Mexico City, 04510, Mexico
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