Responses of circulating urea cycle and branched-chain amino acids to feeding in adult and aged Fischer-344 rats
Por:
Hartman W.J., Seyoum E., Villalobos-Molina R., Joseph J.A., Prior R.L.
Publicada:
1 ene 1997
Resumen:
Amino acid concentrations in plasma and blood were compared between adult (6 months) and aged (22 months) male rats in fed and food-deprived (fasted) states. Since feeding is known to elevate plasma amino acids, rats were sampled after food had been freely available to them and after food was withheld for 20 hours. Fourteen amino acids increased (8 to 74%) in blood and plasma in fed rats compared to food-deprived rats. Blood concentrations of four amino acids (cystine, aspartate, threonine, and phosphoserine) were increased in aged compared to adult rats, while tyrosine was 10% lower. The interaction between fed state and age was significant for the branched-chain amino acids (BCAA) as they increased 23% in the blood and plasma of fed compared to food-deprived adult rats; however, BCAA were not affected by feeding state in the aged rats. Plasma arginine concentration was 12% lower (p
Filiaciones:
Hartman W.J.:
U.S. Department of Agriculture, Agricultural Research Service, Jean Mayer USDA Hum. Nutr. Res. C., Boston, MA, United States
Seyoum E.:
U.S. Department of Agriculture, Agricultural Research Service, Jean Mayer USDA Hum. Nutr. Res. C., Boston, MA, United States
Villalobos-Molina R.:
U.S. Department of Agriculture, Agricultural Research Service, Jean Mayer USDA Hum. Nutr. Res. C., Boston, MA, United States
Joseph J.A.:
U.S. Department of Agriculture, Agricultural Research Service, Jean Mayer USDA Hum. Nutr. Res. C., Boston, MA, United States
Prior R.L.:
U.S. Department of Agriculture, Agricultural Research Service, Jean Mayer USDA Hum. Nutr. Res. C., Boston, MA, United States
USDA-ARS HNRCA, 711 Washington Street, Boston, MA 02111, United States
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