Increased neural activity in transgenic mice with brain IGF-I overexpression: A [3H]2DG study
Por:
Gutiérrez-Ospina G., Saum L., Calikoglu A.S., Díaz-Cintra S., Barrios F.A., D'Ercole A.J.
Publicada:
1 ene 1997
Resumen:
TO evaluate whether insulin-like growth factor-I (IGF-I) modulates neural activity in vivo, relative levels of brain [3H]2-deoxyglucose (2DG) uptake were compared in adult behaving and anesthetized wild type (wt) mice, and transgenic (Tg) mice with either brain IGF-I over-expression or ectopic brain expression of IGF binding protein-1 (IGFBP-1). Overall, awake behaving IGF-I Tg mice showed significant increases in brain 2DG uptake compared with wt and IGFBP-1 Tg mice. These differences were eliminated after anesthesia. 2DG uptake was similar in awake behaving, and anesthetized wt and IGFBP-1 Tg mice. Our observations thus suggest that IGF-I increases neural activity levels in vivo, and that it is not involved in regulating glucose consumption in the adult brain.
Filiaciones:
Gutiérrez-Ospina G.:
Department of Pediatrics, Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599-7220, United States
Dept. of Developmental Neurobiology, Center of Neurobiology, National University of México, Apdo. P. 1-1141, Gen. Arteaga No.5, Qro C.P. 76001, Mexico
Saum L.:
Department of Pediatrics, Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599-7220, United States
Calikoglu A.S.:
Department of Pediatrics, Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599-7220, United States
Díaz-Cintra S.:
Dept. of Developmental Neurobiology, Center of Neurobiology, National University of México, Apdo. P. 1-1141, Gen. Arteaga No.5, Qro C.P. 76001, Mexico
Barrios F.A.:
Dept. of Developmental Neurobiology, Center of Neurobiology, National University of México, Apdo. P. 1-1141, Gen. Arteaga No.5, Qro C.P. 76001, Mexico
D'Ercole A.J.:
Department of Pediatrics, Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599-7220, United States
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