On the protection by ketorolac of reperfusion-induced heart damage
Por:
Chávez E., Téllez F., Pichardo J., Milán R., Cuéllar A., Carbajal K., Cruz D.
Publicada:
1 ene 1996
Resumen:
This study shows that the nonsteroidal antiinflammatory drug, ketorolac, protects against myocardial damage induced by reperfusion. This effect was analyzed after 5 min of coronary occlusion in rat hearts. The results indicate that ketorolac, at a dose of 1 mg/kg, effectively protects the heart against reperfusion arrhythmias. Furthermore, it protects from the release of lactate dehydrogenase and creatine kinase to the plasma. We propose that the protective effect of the drug might be due to its chelating action on calcium ions, thus preventing the overload of such cation in myocardial cells. Copyright (C) 1996 Elsevier Science Inc.
Filiaciones:
Chávez E.:
Departamento de Bioquímica, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
Dept. Bioquímica, Inst. Nal. de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, México, D.F. 014080, Mexico
Téllez F.:
Departamento de Bioquímica, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
Pichardo J.:
Departamento de Bioquímica, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
Milán R.:
Departamento de Bioquímica, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
Cuéllar A.:
Departamento de Bioquímica, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
Carbajal K.:
Departamento de Bioquímica, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
Cruz D.:
Departamento de Patología, Inst. Nacional de Cardiología, Ignacio Chávez, Juan Badiano No. 1, Tlalpam, D.F. 014080, Mexico
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