Immune response to porins isolated from Salmonella typhi in different mouse strains
Por:
Gonzalez C.R., Mejia M.V., Paniagua J., Orttz-Navarrete V., Ramirez G., Isibasi A.
Publicada:
1 ene 1995
Resumen:
Outer membrane proteins (OMPs) are able to induce protection against the challenge with S. typhi in a murine model. Both humoral and cellular immunity are involved in the protective mechanisms. In order to determine whether the responsiveness to S. typhi porins is genetically controlled in mice, different strains were immunized i.p. with 30 ?g of OMPs isolated from S. typhi 9,12,Vi:d at days 0 and 7. On day 21, spleen cells were recovered and the lymphoproliferative response to porins was assessed. The highest responses were found in mice with H-2(k) and H-2a haplotypes (C3H/HeJ and A/J), intermediate responses were found in mice with H-2b haplotype (C57B1/6) and the lowest repsonses in H-2(d) mice (Balb/c). These results demonstrate that the responsiveness to S. typhi porins is in part controlled by the major histocompatibility complex class II molecules and will help to further study the mechanisms of the immune response to these proteins.
Filiaciones:
Gonzalez C.R.:
Unidad Invest. Medica Inmunoquimica, Hospital de Especialidades, CMN Siglo XXI, Aptdo Postal 73-032, 03020 Mexico DF, Mexico
Mejia M.V.:
Unidad Invest. Medica Inmunoquimica, Hospital de Especialidades, CMN Siglo XXI, Aptdo Postal 73-032, 03020 Mexico DF, Mexico
Paniagua J.:
Unidad Invest. Medica Inmunoquimica, Hospital de Especialidades, CMN Siglo XXI, Aptdo Postal 73-032, 03020 Mexico DF, Mexico
Orttz-Navarrete V.:
Unidad Invest. Medica Inmunoquimica, Hospital de Especialidades, CMN Siglo XXI, Aptdo Postal 73-032, 03020 Mexico DF, Mexico
Ramirez G.:
Unidad Invest. Medica Inmunoquimica, Hospital de Especialidades, CMN Siglo XXI, Aptdo Postal 73-032, 03020 Mexico DF, Mexico
Isibasi A.:
Unidad Invest. Medica Inmunoquimica, Hospital de Especialidades, CMN Siglo XXI, Aptdo Postal 73-032, 03020 Mexico DF, Mexico
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