Human cell mediated immunity to porins from salmonella typhi
Por:
Blanco F., Isibasi A., González C.R., Ortiz V., Paniagua J., Arreguín C., Kumate J.
Publicada:
1 ene 1993
Resumen:
The current studies were undertaken to assess the role of the porins and outer membrane proteins (OMP) in the human immune response to Salmonella typhi 9,12 Vi:d. Experiments were performed to determinate the lymphocyte activation response to porins in individuals who had been vaccinated against typhoid fever. 10 healthy volunteers were studied before and 10 days after oral or subcutaneous immunisation. Five patients with typhoid fever were also studied. Lymphocyte activation was measured by the 3H thymidine incorporation assay. Individuals with typhoid fever as well as those immunised with oral vaccine responded well to porins and outer membrane proteins, as opposed to those immunised with the subcutaneous vaccine. These results suggest that the porins and OMP play a role in the cellular immune response against Salmonella typhi. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Filiaciones:
Blanco F.:
Laboratory of Immunochemistry, Unidad de Investigatión Biomédica, Institute Mexicano del Seguro Social, México City, Mexico
Isibasi A.:
Laboratory of Immunochemistry, Unidad de Investigatión Biomédica, Institute Mexicano del Seguro Social, México City, Mexico
González C.R.:
Laboratory of Immunochemistry, Unidad de Investigatión Biomédica, Institute Mexicano del Seguro Social, México City, Mexico
Ortiz V.:
Research Department, Institute National de Higiene, Gerencia General de Biológicos y Reactivos, México City, Mexico
Paniagua J.:
Research Department, Institute National de Higiene, Gerencia General de Biológicos y Reactivos, México City, Mexico
Arreguín C.:
Research Department, Institute National de Higiene, Gerencia General de Biológicos y Reactivos, México City, Mexico
Kumate J.:
The Secretaría de Salud, México City, Mexico
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