Further studies on the mechanism of action of gossypol on mitochondrial membrane
Por:
Cuéllar A., Ramírez J.
Publicada:
1 ene 1993
Resumen:
1. 1. In order to explore the mechanism of inhibition of hydroxylases involved in steroidogenesis, by gossypol, we studied the effect of this drug on adrenal cortex mitochondria, and compared it with those on kidney and heart. 2. 2. The uncoupler effect of gossypol (collapse of ?? and Ca2+ efflux) was found to be lower in adrenal cortex mitochondria than in kidney and heart mitochondria. 3. 3. Gossypol produced more extensive changes on the membrane lipidic matrix (increase in the order parameter for 5-doxylstearic acid) in adrenal cortex mitochondria than in the other mitochondria studied. 4. 4. The results described above indicate that the mechanism of inhibition of gossypol of steroidogenic adrenal enzymes could be attributed to an alteration of the lipidic matrix which, in turn, modifies protein function. © 1993.
Filiaciones:
Cuéllar A.:
Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badino 1, Tlalpan, México, D. F. 14080, Mexico
Ramírez J.:
Departamento de Microbiología, Instituto de Fisiología Celular UNAM, México, D. F., 04510 México [Fax 525-573-0926]
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