Immunodiagnosis of Neurocysticercosis: Disappointing Performance of Serology (Enzyme-Linked Immunosorbent Assay) in an Unbiased Sample of Neurological Patients
Por:
Ramos Kuri M., Sotelo J., Montoya R.M., Padilla A., Govezensky T., Diaz M.L., Sciutto E., Larralde C.
Publicada:
1 ene 1992
Resumen:
To ascertain the reliability of serological diagnosis of neurocysticercosis in the everyday a priori situation of neurological consultation, the enzyme-linked immunosorbent assay test was used to predict the eventual diagnosis of neurocysticercosis in an unselected sample of 1064 consecutive neurological cases. Results showed 69% sensitivity and 71% specificity of the enzyme-linked immunosorbent assay test for the diagnosis of neurocysticercosis. In sharp contrast with publications that have proclaimed the excellent diagnostic performance of immunodiagnostic tests, our results suggest that identification of serum antibodies with standard enzyme-linked immunosorbent assay techniques is of little value when applied to a large and heterogeneous group of neurological patients in an endemic area of cysticercosis, and our results urge a reevaluation of currently used immunodiagnostic tests that are practiced in the serum of suspected cases. © 1992 IEEE All rights reserved.
Filiaciones:
Ramos Kuri M.:
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
Sotelo J.:
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico
Montoya R.M.:
Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City, Mexico
Padilla A.:
Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City, Mexico
Govezensky T.:
Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City, Mexico
Diaz M.L.:
Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City, Mexico
Sciutto E.:
Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City, Mexico
Larralde C.:
Institute of Biomedical Investigations, National Autonomous University of Mexico, Mexico City, Mexico
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