CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1
Por:
Rosenstein Y., Park J.K., Hahn W.C., Rosen F.S., Bierer B.E., Burakoff S.J.
Publicada:
1 ene 1991
Resumen:
THE protein CD43 (also known as sialophorin, leukosialin, large sialoglycoprotein or gp115) is expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets and some B lymphocytes1-6. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome7, suggesting that CD43 might have a role in T-cell activation. We have shown that expression of human CD43 in an HLA-DR-specific murine T-cell hybridoma enhances the antigen-specific response to stimulation by the human lympho-blastoid cell line Daudi, and that Daudi cells bind specifically to purified immobilized CD43 (ref. 8). These data indicate that the specific interaction of CD43 with a ligand on the surface of Daudi cells might contribute to T-cell activation. Here we report evidence that intercellular adhesion molecule-1 (ICAM-1, or CD54), is a ligand for CD43. © 1991 Nature Publishing Group.
Filiaciones:
Rosenstein Y.:
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital
Department of Pathology, Harvard Medical School, Boston, MA 02115, United States
Park J.K.:
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital
Hahn W.C.:
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital
Rosen F.S.:
Center for Blood Research, Brigham and Women's Hospital
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States
Bierer B.E.:
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital
Hematology-Oncology Division, Brigham and Women's Hospital
Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
Burakoff S.J.:
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States
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